Copyright © 2004, European Society of Cardiology
Update on therapeutic neovascularization
aLaboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden
bBioengineering Institute of Jinan University, Shipai, Tianhe District, Guangzhou, 510632, People's Republic of China
cDepartment of Physiology, CARIM, Maastricht University, Maastricht, The Netherlands
* Corresponding authors. Mark J. Post is to be contacted at Tel.: +31 43 3881200; fax: +31 43 3884166. Yihai Cao, Tel.: +46 8 728 7596; fax: +46 8 31 9470. Email address: yihai.cao{at}mtc.ki.se m.post{at}fys.unimaas.nl
Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is anticipated that this will lose significance as the pleiotropic nature of angiogenic cytokines becomes fully understood. With the rapidly growing body of data on growth factors and pro-angiogenic strategies, approaches will emerge that are more effective than the ones that have been tested clinically thus far. Combinations of growth factors, for instance to stabilize vessels, or growth factors combined with cell transplants deserve more attention but will make the design of preclinical and clinical studies increasingly complex. Recent developments suggest that when using the appropriate dose and treatment regimens, even single growth factor therapy can result in stable and functional vessels. Whether gene therapy or protein therapy will be optimal for this purpose depends mainly on technical developments in vector design and production and on progress in the engineering of slow release matrix formulations for proteins.
With the increasing complexity of therapeutic strategies, it remains imperative that these approaches are rationally based on fundamental and preclinical data.
KEYWORDS Ischemia; Neovascularization; Angiogenesis; Growth factors
Time for primary review 28 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Zhang, Y. Liu, X. T. Lu, Y. L. Wu, C. Zhang, X. P. Ji, R. Wang, C. X. Liu, J. B. Feng, H. Jiang, et al. Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2004 - H2014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dahl Ejby Jensen, R. Cao, E.-M. Hedlund, I. Soll, J. O. Lundberg, G. Hauptmann, J. F. Steffensen, and Y. Cao Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish PNAS, October 27, 2009; 106(43): 18408 - 18413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rafat, G. Ch. Beck, P. G. Pena-Tapia, P. Schmiedek, and P. Vajkoczy Increased Levels of Circulating Endothelial Progenitor Cells in Patients With Moyamoya Disease Stroke, February 1, 2009; 40(2): 432 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Benest, O. A. Stone, W. H. Miller, C. P. Glover, J. B. Uney, A. H. Baker, S. J. Harper, and D. O. Bates Arteriolar Genesis and Angiogenesis Induced by Endothelial Nitric Oxide Synthase Overexpression Results in a Mature Vasculature Arterioscler Thromb Vasc Biol, August 1, 2008; 28(8): 1462 - 1468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rajagopalan, J. Olin, S. Deitcher, A. Pieczek, J. Laird, P. M. Grossman, C. K. Goldman, K. McEllin, R. Kelly, and N. Chronos Use of a Constitutively Active Hypoxia-Inducible Factor-1{alpha} Transgene as a Therapeutic Strategy in No-Option Critical Limb Ischemia Patients: Phase I Dose-Escalation Experience Circulation, March 13, 2007; 115(10): 1234 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhou, F. X. Ma, P. X. Liu, Z. H. Fang, S. L. Wang, Z. B. Han, M.-C. Poon, and Z. C. Han Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells J. Lipid Res., March 1, 2007; 48(3): 518 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Murphy, B. Larrivee, I. Pollet, K. S. Craig, D. E. Williams, X.-H. Huang, M. Abbott, F. Wong, C. Curtis, T. P. Conrads, et al. Identification of Sokotrasterol Sulfate As a Novel Proangiogenic Steroid Circ. Res., August 4, 2006; 99(3): 257 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sun and K. R. McCrae Endothelial-cell apoptosis induced by cleaved high-molecular-weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species Blood, June 15, 2006; 107(12): 4714 - 4720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Napoli, S. Williams-Ignarro, F. de Nigris, G. de Rosa, L. O. Lerman, B. Farzati, A. Matarazzo, G. Sica, C. Botti, A. Fiore, et al. Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb PNAS, November 22, 2005; 102(47): 17202 - 17206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Mould, S. A. Greco, M. M. Cahill, I. D. Tonks, D. Bellomo, C. Patterson, A. Zournazi, A. Nash, P. Scotney, N. K. Hayward, et al. Transgenic Overexpression of Vascular Endothelial Growth Factor-B Isoforms by Endothelial Cells Potentiates Postnatal Vessel Growth In Vivo and In Vitro Circ. Res., September 16, 2005; 97(6): e60 - e70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Friedrich and M. Bohm Human umbilical cord blood cells and myocardial infarction: Novel ways to treat an old problem Cardiovasc Res, April 1, 2005; 66(1): 4 - 6. [Full Text] [PDF]
|
|
|
|
|
|
M. Post and J. Waltenberger Modulation of growth factor action in the cardiovascular system Cardiovasc Res, February 15, 2005; 65(3): 547 - 549. [Full Text] [PDF]
|
|