Skip Navigation

Cardiovascular Research 2005 65(3):609-618; doi:10.1016/j.cardiores.2004.10.002
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Martínez-González, J.
Right arrow Articles by Badimon, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martínez-González, J.
Right arrow Articles by Badimon, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004, European Society of Cardiology

The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells

José Martínez-González and Lina Badimon*

Centro de Investigación Cardiovascular, CSIC/ICCC, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret #167, Barcelona, Spain

* Corresponding author. Tel.: +34 935565882; fax: +34 935565559. Email address: lbadimon{at}csic-iccc.santpau.es

The molecular mechanisms regulating endothelial cell activation and vascular smooth muscle cell proliferation are critical in the pathological processes underlying atherosclerosis. Numerous growth factors and cytokines trigger the complex and redundant signaling pathways that regulate cell cycle entry; however, the genes controlling these processes are not fully known. Applying techniques for differential gene expression analysis, new transcription factors have been identified in these mechanisms, among them the three members of the NR4A subfamily of nuclear receptors (NRs). These transcription factors (NOR-1, Nur77 and Nurr1) are products of immediate–early genes whose expression and activity is regulated in a cell-specific manner by a variety of extracellular mitogenic, apoptotic and differentiation stimuli. Unlike most NRs whose transcriptional activity is regulated by direct modulatory ligands, NR4A genes do not appear to require ligand binding for activation, and in vascular cells they are highly responsive to growth factors, cytokines, lipoproteins and thrombin. In this review, we discuss our present knowledge on the role of this subfamily of NRs in vascular cell function.

KEYWORDS Atherosclerosis; Smooth muscle; Receptors; Gene expression; Signal transduction

Time for primary review 29 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. G. Smith, N. Luk, R. A. Newton, D. W. Roberts, R. A. Sturm, and G. E. O. Muscat
Melanocortin-1 Receptor Signaling Markedly Induces the Expression of the NR4A Nuclear Receptor Subgroup in Melanocytic Cells
J. Biol. Chem., May 2, 2008; 283(18): 12564 - 12570.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
D. A. Dalmas, M. S. Scicchitano, Y. Chen, J. Kane, R. Mirabile, L. W. Schwartz, H. C. Thomas, and R. W. Boyce
Transcriptional Profiling of Laser Capture Microdissected Rat Arterial Elements: Fenoldopam-induced Vascular Toxicity as a Model System
Toxicol Pathol, April 1, 2008; 36(3): 496 - 519.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Hollborn, M. Francke, I. Iandiev, E. Buhner, C. Foja, L. Kohen, A. Reichenbach, P. Wiedemann, A. Bringmann, and S. Uhlmann
Early Activation of Inflammation- and Immune Response-Related Genes after Experimental Detachment of the Porcine Retina
Invest. Ophthalmol. Vis. Sci., March 1, 2008; 49(3): 1262 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Crespo, J. Martinez-Gonzalez, J. Rius, and L. Badimon
Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation
Cardiovasc Res, August 1, 2005; 67(2): 333 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Post and J. Waltenberger
Modulation of growth factor action in the cardiovascular system
Cardiovasc Res, February 15, 2005; 65(3): 547 - 549.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.