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Cardiovascular Research 2005 65(3):587-598; doi:10.1016/j.cardiores.2004.08.016
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Copyright © 2005, European Society of Cardiology

Tyrosine phosphatases in vessel wall signaling

Kai Kapperta, Kevin G. Petersb, Frank D. Böhmerc and Arne Östmana,*

aCancer Center Karolinska, Department Of Oncology and Pathology, R8:03, Karolinska Institutet, 171 76 Stockholm, Sweden
bProcter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Box 1064, Mason, OH 45040, USA
cInstitute of Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, D-07747 Jena, Germany

* Corresponding author. Tel.: +46 8 5177 0232; fax: +46 8 33 90 31. Email address: Arne.Ostman{at}cck.ki.se

Protein tyrosine phosphatases (PTPs) are critical regulators of cellular processes like migration, proliferation and differentiation that are involved in physiological and pathological vessel wall function. In this review, we summarize the biochemistry of this enzyme family, discuss the present knowledge concerning the identity and involvement of PTPs in vascular cells and in pathways of relevance to cardiovascular diseases. We also briefly introduce ongoing efforts to develop inhibitors of PTPs, and finally point to some opportunities for use of such agents in novel treatment strategies.

KEYWORDS Protein tyrosine phosphatase; Cardiovascular disease; Cell signaling; Angiogenesis; Antherogenesis

Time for primary review 29 days


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