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Cardiovascular Research 2005 65(3):547-549; doi:10.1016/j.cardiores.2004.12.006
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Copyright © 2004, European Society of Cardiology

Modulation of growth factor action in the cardiovascular system

Mark Posta,* and Johannes Waltenbergerb,*

aDepartment of Physiology, University of Maastricht, Cardiovascular Research Institute of Maastricht (CARIM), Universiteitssingel 50, 6200 UM Maastricht, The Netherlands
bDepartment of Cardiology, University Hospital of Maastricht, Cardiovascular Research Institute of Maastricht (CARIM), P. Debyelaan 25, P.O. Box 5800, NL-6202 AZ Maastricht, The Netherlands

* Corresponding authors. Johannes Waltenberger is to be contacted at Tel.: +31 43 38 75 106; fax: +31 43 38 75 104. Mark J. Post, Tel.: +31 43 38 81 085; fax: +31 43 38 84 166. Email address: m.post@fys.unimaas.nl j.waltenberger@cardio.azm.nl

Received 6 December 2004; accepted 14 December 2004

The first 10% of the full text of this article appears below.

When the Nobel prize for physiology and medicine was awarded for the discovery of the first peptide growth factors to Rita Levi-Montalcini and Stanley Cohen in 1986, Russel Ross in Seattle was among the first to realize the potential power of growth factors in mediating vascular function and dysfunction with regard to the proliferative activity associated with the development of human atherosclerotic lesions [1].

The concept of growth factors in the vascular literature has been a success story. This is true for the cardiovascular field related to atherosclerosis, angiogenesis, arteriogenesis and collateral artery growth, but maybe even more so for the field of tumor angiogenesis as introduced by Judah Folkman in 1971 [2]. The clinical success of growth factor-directed and -related therapy is exemplified by two growth . . . [Full Text of this Article]


   1. The state-of-the-art of growth factor biology and growth factor therapy in the vascular system
 
1.1. The biology of growth factor function in the vessel wall
1.2. Growth factor biology as a key to understand cardiovascular pathology and pathophysiology
1.3. Growth factors as novel therapeutic tools

   2. Perspectives for the growth factor field
 

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