Copyright © 2004, European Society of Cardiology
Structural and functional characterisation of cardiac fibroblasts
aUniversity Laboratory of Physiology, Oxford, OX1 3PT, UK
bDepartment of Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC, United States
* Corresponding author. Fax: +44 1865 272554. Email address: peter.kohl{at}physiol.ox.ac.uk
Cardiac fibroblasts form one of the largest cell populations, in terms of cell numbers, in the heart. They contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, they are often disregarded by in vivo and in vitro studies into cardiac function. This review summarizes our understanding of fibroblast origin and identity, their structural organization and role in myocardial architecture, as well as functional aspects related to cell signalling and electro-mechanical function in the heart.
KEYWORDS Connective tissue; Myocardium; Remodelling; Gap junction; Heart
Time for primary review 27 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Snider, K. N. Standley, J. Wang, M. Azhar, T. Doetschman, and S. J. Conway Origin of Cardiac Fibroblasts and the Role of Periostin Circ. Res., November 6, 2009; 105(10): 934 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jankowski GATA4, a new regulator of cardiac fibroblasts, is sensitive to natriuretic peptides Cardiovasc Res, November 1, 2009; 84(2): 176 - 177. [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Kosloski, I. K. Bales, K. B. Allen, B. L. Walker, A. M. Borkon, R. S. Stuart, A. F. Pak, and M. J. Wacker Purification of cardiac myocytes from human heart biopsies for gene expression analysis Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1163 - H1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Turner, A. Das, P. Warburton, D. J. O'Regan, S. G. Ball, and K. E. Porter Interleukin-1{alpha} stimulates proinflammatory cytokine expression in human cardiac myofibroblasts Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1117 - H1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Pedrotty, R. Y. Klinger, R. D. Kirkton, and N. Bursac Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes Cardiovasc Res, September 1, 2009; 83(4): 688 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. McSpadden, R. D. Kirkton, and N. Bursac Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level Am J Physiol Cell Physiol, August 1, 2009; 297(2): C339 - C351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xie, A. Garfinkel, J. N. Weiss, and Z. Qu Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H775 - H784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Banerjee, J. W. Fuseler, A. R. Intwala, and T. A. Baudino IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1694 - H1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Manso, S.-M. Kang, S. V. Plotnikov, I. Thievessen, J. Oh, H. E. Beggs, and R. S. Ross Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H627 - H638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Huang, C. Yang, Y. Wang, Y. Liao, and K. Huang PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR{gamma} in cardiac fibroblasts Cardiovasc Res, January 1, 2009; 81(1): 98 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Totlandsdal, M. Refsnes, T. Skomedal, J.-B. Osnes, P. E. Schwarze, and M. Lag Particle-Induced Cytokine Responses in Cardiac Cell Cultures--the Effect of Particles versus Soluble Mediators Released by Particle-Exposed Lung Cells Toxicol. Sci., November 1, 2008; 106(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cabo Modulation of impulse propagation by fibroblasts Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H1992 - H1993. [Full Text] [PDF]
|
|
|
|
|
|
V. P. Singh, K. M. Baker, and R. Kumar Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1675 - H1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Pillai, M. Chen, S. B. Rajamohan, S. Samant, V. B. Pillai, M. Gupta, and M. P. Gupta Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the {alpha}-myosin heavy chain expression Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1388 - H1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Olson, P. E. Shamhart, J. E. Naugle, and J. G. Meszaros Angiotensin II-Induced Extracellular Signal-Regulated Kinase 1/2 Activation Is Mediated by Protein Kinase C{delta} and Intracellular Calcium in Adult Rat Cardiac Fibroblasts Hypertension, March 1, 2008; 51(3): 704 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. LaCroix, J. Freeling, A. Giles, J. Wess, and Y.-F. Li Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H810 - H820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zurney, K. E. Howard, and B. Sherry Basal Expression Levels of IFNAR and Jak-STAT Components Are Determinants of Cell-Type-Specific Differences in Cardiac Antiviral Responses J. Virol., December 15, 2007; 81(24): 13668 - 13680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Fahrenbach, R. Mejia-Alvarez, and K. Banach The relevance of non-excitable cells for cardiac pacemaker function J. Physiol., December 1, 2007; 585(2): 565 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Husse, W. Briest, L. Homagk, G. Isenberg, and M. Gekle Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1898 - R1907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Jacquemet and C. S. Henriquez Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation Europace, November 1, 2007; 9(suppl_6): vi29 - vi37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baruscotti and R. B. Robinson Electrophysiology and pacemaker function of the developing sinoatrial node Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2613 - H2623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Pijnappels, J. van Tuyn, A. A.F. de Vries, R. W. Grauss, A. van der Laarse, D. L. Ypey, D. E. Atsma, and M. J. Schalij Resynchronization of Separated Rat Cardiomyocyte Fields With Genetically Modified Human Ventricular Scar Fibroblasts Circulation, October 30, 2007; 116(18): 2018 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Spruill, A. S. Lowry, R. E. Stroud, C. E. Squires, I. M. Mains, E. C. Flack, C. Beck, J. S. Ikonomidis, A. J. Crumbley, P. J. McDermott, et al. Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1362 - C1373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Banerjee, J. W. Fuseler, R. L. Price, T. K. Borg, and T. A. Baudino Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1883 - H1891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K Parker and D. E Ingber Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering Phil Trans R Soc B, August 29, 2007; 362(1484): 1267 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gurjarpadhye, K. W. Hewett, C. Justus, X. Wen, H. Stadt, M. L. Kirby, D. Sedmera, and R. G. Gourdie Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1291 - H1300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zebedin, M. Mille, M. Speiser, T. Zarrabi, W. Sandtner, B. Latzenhofer, H. Todt, and K. Hilber C2C12 skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H439 - H450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Podgorska, K. Kocbuch, M. Grden, A. Szutowicz, and T. Pawelczyk Reduced ability to release adenosine by diabetic rat cardiac fibroblasts due to altered expression of nucleoside transporters J. Physiol., October 1, 2006; 576(1): 179 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Baudino, W. Carver, W. Giles, and T. K. Borg Cardiac fibroblasts: friend or foe? Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1015 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Sweitzer, S. A. Fann, T. K. Borg, J. W. Baynes, and M. J. Yost What is the future of diabetic wound care? The Diabetes Educator, March 1, 2006; 32(2): 197 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kohl, P. Camelliti, F. L Burton, and G. L Smith Fibroblast-Myocyte Interrelation in the Mammalian Heart: Experiments and Models FASEB J, March 1, 2006; 20(5): A847 - A847.
|
|
|
|
 |
|
 M. L. Trew, B. J. Caldwell, G. B. Sands, D. A. Hooks, D. C.-S. Tai, T. M. Austin, I. J. LeGrice, A. J. Pullan, and B. H. Smaill Cardiac electrophysiology and tissue structure: bridging the scale gap with a joint measurement and modelling paradigm Exp Physiol, March 1, 2006; 91(2): 355 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Haverinen and M. Vornanen Significance of Na+ current in the excitability of atrial and ventricular myocardium of the fish heart J. Exp. Biol., February 1, 2006; 209(3): 549 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hunt and D. R. Brown Mycoplasma alligatoris Infection Promotes CD95 (FasR) Expression and Apoptosis of Primary Cardiac Fibroblasts Clin. Vaccine Immunol., December 1, 2005; 12(12): 1370 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tamaoki, K. Imanaka-Yoshida, K. Yokoyama, T. Nishioka, H. Inada, M. Hiroe, T. Sakakura, and T. Yoshida Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury Am. J. Pathol., July 1, 2005; 167(1): 71 - 80. [Abstract] [Full Text] [PDF]
|
|