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Cardiovascular Research 2005 65(1):13-15; doi:10.1016/j.cardiores.2004.10.015
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Copyright © 2004, European Society of Cardiology

Phospholemman, a chaperone of Na+,K+-ATPase?

Paul Fransen*

Laboratory of Physiopharmacology, Department of Pharmacology, University of Antwerp, CDE, Universiteitsplein 1, B-2610 Antwerp, Belgium

* Tel.: +32 3 820 25 87; fax: +32 3 820 25 67. Email address: paul.fransen@ua.ac.be

Received 1 October 2004; accepted 13 October 2004

The first 10% of the full text of this article appears below.

See article by Silverman et al. [8] (pages 93–103) in this issue.

Control of intracellular Na+ homeostasis is of crucial importance for normal functioning of the heart. Na+ extrusion in cardiomyocytes occurs mainly via the sodium pump or Na+,K+-ATPase. This enzyme consists of a catalytic {alpha}-subunit with binding sites for ATP, Na+, K+ and cardiac glycosides, and a glycoprotein β-subunit. The main function of this pump in cardiac myocytes is to maintain and restore ion gradients for Na+ and K+ during electrical activity by mediating active transport of 3Na+ out and 2K+ into the cell. Of the four {alpha}-isoforms, {alpha}1, {alpha}2 and {alpha}3 have been described in cardiac tissue, . . . [Full Text of this Article]


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