© 2004 by European Society of Cardiology
Copyright © 2004, European Society of Cardiology
Identifying and understanding the role of pulmonary vein activity in atrial fibrillation
McGill University, Faculty of Medicine, 3550 Jeanne Mance, Apt. 1811E, Montreal, Quebec, Canada H2X 3P7
* Tel.: +1 514 287 7617. Email address: razi.khan{at}mail.mcgill.ca
The perception of atrial fibrillation development has changed drastically over the last decade. The pulmonary veins have been targeted as the source of arrhythmogenic activity involved in the initiation of atrial fibrillation. This activity appears to be localized in the myocardial sleeves of the vessels. Extensive study of cells within this tissue has helped create a new model for atrial fibrillation. This review attempts to show how the development, architecture and electrophysiologic properties of the pulmonary veins influence the initiation and perpetuation of atrial fibrillation. It also examines the potential long-term effects of pulmonary vein activity on arrhythmia development.
KEYWORDS Pulmonary veins; Atrial fibrillation; Atrial remodeling; Atrial fibrosis
Time for primary review 22 days
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