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Cardiovascular Research 2004 64(2):337-345; doi:10.1016/j.cardiores.2004.06.025
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

Transendothelial exchange of low-density lipoprotein is unaffected by the presence of severe atherosclerosis

Karen Kornerupa, Børge Grønne Nordestgaardb,c, Trine Krogsgaard Jensena, Bo Feldt-Rasmussena, Jonas Peter Eibergd, Kurt Svarre Jensena and Jan Skov Jensena,c,e,*

aDepartment of Nephrology and Endocrinology P, The National University Hospital, Copenhagen, Denmark
bDepartment of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
cThe Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark
dDepartment of Vascular Surgery RK, The National University Hospital, Copenhagen, Denmark
eDepartment of Cardiology B, The National University Hospital, Copenhagen, Denmark

* Corresponding author. Department of Cardiology P, Gentofte University Hospital, post 163, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark. Tel.: +4539777450; fax: +4539777117. Email address: jsje{at}c.dk

Objective: We tested the hypothesis that transendothelial exchange of low-density lipoprotein (LDL) is influenced by the presence of severe atherosclerosis; we previously found this exchange elevated in diabetes patients.

Methods: By an in vivo isotope method, we compared transendothelial LDL exchange in 24 patients with angiographically verified coronary atherosclerosis, 11 patients with angiographically verified peripheral atherosclerosis, 60 patients with diabetes, and in 42 controls. Autologous 131-iodinated LDL (131I-LDL) and 125-iodinated albumin (125I-albumin) were injected intravenously (i.v.), and the 1-h fractional escape rates (FERLDL and FERalb) were taken as indices of transendothelial exchange.

Results: Patients with coronary or peripheral atherosclerosis had FERLDL similar to that of controls [4.3 (3.5–5.1) and 3.2 (2.3–4.1) versus 4.2 (3.7–4.7)%/h; P>0.05], even after adjustment for LDL distribution volume (DVLDL). In contrast, diabetes patients had significantly higher FERLDL than controls [5.2 (4.6–5.7) versus 4.2 (3.7–4.7)%/h; P<0.05]. This difference was even more pronounced after correction for the distribution volume of LDL. Compared with controls, FERalb was not elevated in patients with coronary atherosclerosis, possibly elevated in patients with peripheral atherosclerosis, but was elevated in diabetes patients. There was a tight positive correlation between FERLDL and FERalb in all groups of patients and controls.

Conclusion: Transendothelial exchange of low-density lipoprotein is not elevated in patients having severe atherosclerosis. This suggests that the observed vascular leakiness in diabetes precedes and possibly contributes to accelerated atherosclerosis in diabetes.

KEYWORDS Capillary permeability; Diabetes; Lipid metabolism; Lipoproteins

Time for primary review 27 days


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