© 2004 by European Society of Cardiology
Copyright © 2004, European Society of Cardiology
Network integration of the adrenergic system in cardiac hypertrophy
Departments of Medicine, Cell Biology and Molecular Genetics, Duke University Medical Center, DUMC 3104 226 CARL Building, Research Drive, Durham, NC 27710 USA
* Corresponding author. Tel.: +1-919-668-2520; fax: +1-919-668-2524. Email address: h.rockman{at}duke.edu
Adrenergic receptors play a pivotal role in regulating cardiac function in response to a constantly changing environment. Altered 
and β adrenergic receptor signaling in vivo is associated with cardiac hypertrophy and failure. This review focuses on the different roles of adrenergic receptors in regulating cardiac function under normal and pathological conditions. Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure.
KEYWORDS Adrenergic receptors; Heart failure; Cardiac hypertrophy
Time for primary review 16 days
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