© 2004 by European Society of Cardiology
Copyright © 2004, European Society of Cardiology
GATA transcription factors in the developing and adult heart
Department of Pharmacology and Toxicology, Faculty of Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland
* Corresponding author. Tel.: +358-8-5375236; fax: +358-8-5375247. Email address: heikki.ruskoaho{at}oulu.fi
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development and growth as well as in cardiac hypertrophy and heart failure. GATA-4, -5 and -6 are zinc finger transcription factors that are expressed in the developing heart and GATA-4 and -6 continue expression in the adult cardiac myocytes. GATA-4 and -6 regulate expression of several cardiac-specific genes, and during murine embryonic development, GATA-4 is essential for proper cardiac morphogenesis. In support of this, mutations of gene for GATA-4 or for its cofactors have been associated with human congenital heart disease. Pressure overload of the heart in vivo as well as hypertrophic stimulation of cardiac myocytes in vitro provide adequate stimulus for activation of GATA-4. Activity of GATA-4 transcription factor is subject to regulation at the level of gene expression and through post-translational modifications of GATA-4 protein. A number of genes induced during cardiac hypertrophy possess functional GATA sites in their promoter region and cardiac-specific overexpression of GATA-4 or -6 leads to cardiac hypertrophy. In addition, a pattern of interactions between GATA-4 and its numerous cofactors have been identified, showing an increasing complexity in regulatory mechanisms. The present review discusses current evidence of the role and regulation of GATA transcription factors in the heart, with an emphasis in the GATA-4 and development of cardiac hypertrophy.
KEYWORDS GATA-4; GATA-6; Transcription factor; Mitogen-activated protein kinase; Signal transduction; Cardiac hypertrophy; Heart failure
Time for primary review 16 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Jankowski GATA4, a new regulator of cardiac fibroblasts, is sensitive to natriuretic peptides Cardiovasc Res, November 1, 2009; 84(2): 176 - 177. [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Reamon-Buettner, Y. Ciribilli, I. Traverso, B. Kuhls, A. Inga, and J. Borlak A functional genetic study identifies HAND1 mutations in septation defects of the human heart Hum. Mol. Genet., October 1, 2009; 18(19): 3567 - 3578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qian and R. Bodmer Partial loss of GATA factor Pannier impairs adult heart function in Drosophila Hum. Mol. Genet., September 1, 2009; 18(17): 3153 - 3163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Schroder, M. Byse, and J. Satin L-Type Calcium Channel C Terminus Autoregulates Transcription Circ. Res., June 19, 2009; 104(12): 1373 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lavie and P. Lavie Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link Eur. Respir. J., June 1, 2009; 33(6): 1467 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhou, T. A. Francis, H. Yang, W. Tseng, Q. Zhong, B. Frenkel, Edward. E. Morrisey, David. K. Ann, P. Minoo, E. D. Crandall, et al. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1141 - C1150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rojas, S. W. Kong, P. Agarwal, B. Gilliss, W. T. Pu, and B. L. Black GATA4 Is a Direct Transcriptional Activator of Cyclin D2 and Cdk4 and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived Myocardium Mol. Cell. Biol., September 1, 2008; 28(17): 5420 - 5431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Reamon-Buettner, Y. Ciribilli, A. Inga, and J. Borlak A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts Hum. Mol. Genet., May 15, 2008; 17(10): 1397 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takaya, T. Kawamura, T. Morimoto, K. Ono, T. Kita, A. Shimatsu, and K. Hasegawa Identification of p300-targeted Acetylated Residues in GATA4 during Hypertrophic Responses in Cardiac Myocytes J. Biol. Chem., April 11, 2008; 283(15): 9828 - 9835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fisch, S. Gray, S. Heymans, S. M. Haldar, B. Wang, O. Pfister, L. Cui, A. Kumar, Z. Lin, S. Sen-Banerjee, et al. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy PNAS, April 24, 2007; 104(17): 7074 - 7079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharma, J. Masri, O. D. Jo, A. Bernath, J. Martin, A. Funk, and J. Gera Protein Kinase C Regulates Internal Initiation of Translation of the GATA-4 mRNA following Vasopressin-induced Hypertrophy of Cardiac Myocytes J. Biol. Chem., March 30, 2007; 282(13): 9505 - 9516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bisping, S. Ikeda, S. W. Kong, O. Tarnavski, N. Bodyak, J. R. McMullen, S. Rajagopal, J. K. Son, Q. Ma, Z. Springer, et al. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure PNAS, September 26, 2006; 103(39): 14471 - 14476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Tenhunen, J. Rysa, M. Ilves, Y. Soini, H. Ruskoaho, and H. Leskinen Identification of Cell Cycle Regulatory and Inflammatory Genes As Predominant Targets of p38 Mitogen-Activated Protein Kinase in the Heart Circ. Res., September 1, 2006; 99(5): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xin, C. A. Davis, J. D. Molkentin, C.-L. Lien, S. A. Duncan, J. A. Richardson, and E. N. Olson A threshold of GATA4 and GATA6 expression is required for cardiovascular development PNAS, July 25, 2006; 103(30): 11189 - 11194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Konhilas and L. A. Leinwand Partnering Up for Cardiac Hypertrophy Circ. Res., April 28, 2006; 98(8): 985 - 987. [Full Text] [PDF]
|
|
|
|
|
|
T. Oka, M. Maillet, A. J. Watt, R. J. Schwartz, B. J. Aronow, S. A. Duncan, and J. D. Molkentin Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability Circ. Res., March 31, 2006; 98(6): 837 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Backs and E. N. Olson Control of Cardiac Growth by Histone Acetylation/Deacetylation Circ. Res., January 6, 2006; 98(1): 15 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Euler-Taimor and J. Heger The complex pattern of SMAD signaling in the cardiovascular system Cardiovasc Res, January 1, 2006; 69(1): 15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kaneko-Oshikawa, T. Nakagawa, M. Yamada, H. Yoshikawa, M. Matsumoto, M. Yada, S. Hatakeyama, K. Nakayama, and K. I. Nakayama Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System Mol. Cell. Biol., December 15, 2005; 25(24): 10953 - 10964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fischer, J. Klattig, B. Kneitz, H. Diez, M. Maier, B. Holtmann, C. Englert, and M. Gessler Hey Basic Helix-Loop-Helix Transcription Factors Are Repressors of GATA4 and GATA6 and Restrict Expression of the GATA Target Gene ANF in Fetal Hearts Mol. Cell. Biol., October 15, 2005; 25(20): 8960 - 8970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, M. Vingron, and S. A. Haas T-STAG: resource and web-interface for tissue-specific transcripts and genes Nucleic Acids Res., July 1, 2005; 33(suppl_2): W654 - W658. [Abstract] [Full Text] [PDF]
|
|