Skip Navigation

Cardiovascular Research 2004 62(3):460-467; doi:10.1016/j.cardiores.2004.01.011
© 2004 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jöhren, O.
Right arrow Articles by Dominiak, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jöhren, O.
Right arrow Articles by Dominiak, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004, European Society of Cardiology

Cardiovascular and renal function of angiotensin II type-2 receptors

Olaf Jöhren*, Andreas Dendorfer and Peter Dominiak

Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany

* Corresponding author. Tel.: +49-451-500-4357; fax: +49-451-500-3327. Email address: joehren{at}uni-luebeck.de

While all of the well-known cardiovascular and renal effects of angiotensin II (ANG) are attributed to the ANG type-1 (AT1) receptor, much less is known about the function of ANG type-2 (AT2) receptors. This review focuses on progress made in AT2 receptor research over the past 10 years mainly enabled by the availability of AT2 receptor-deficient mice. Two general mechanisms regarding AT2 receptor-mediated actions emerge from recent experiments. Firstly, AT2 receptor stimulation inhibits growth and promotes apoptosis, an important mechanism during development and tissue remodeling. Secondly, ANG stimulates the release of nitric oxide (NO)/cGMP via AT2 receptor activation, as described in the aorta, heart, and kidney. This effect appears to be indirectly mediated by the modulation of bradykinin release. Thus, activation of AT2 receptors may be potentially protective and appears to oppose the effects mediated by AT1 receptors. The question whether AT2 receptors are activated in patients with elevated ANG levels when treated with AT1 receptor antagonists and whether these effects are relevant awaits further clarification.

KEYWORDS Angiotensin; AT2 receptor; Gene deficiency; Apoptosis; Renal function

Time for primary review 29 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
P. M. Cummins
A new addition to the renin-angiotensin peptide family: proAngiotensin-12 (PA12)
Cardiovasc Res, April 1, 2009; 82(1): 7 - 8.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Hosojima, H. Sato, K. Yamamoto, R. Kaseda, T. Soma, A. Kobayashi, A. Suzuki, H. Kabasawa, A. Takeyama, K. Ikuyama, et al.
Regulation of Megalin Expression in Cultured Proximal Tubule Cells by Angiotensin II Type 1A Receptor- and Insulin-Mediated Signaling Cross Talk
Endocrinology, February 1, 2009; 150(2): 871 - 878.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Ohtsu, S. Higuchi, H. Shirai, K. Eguchi, H. Suzuki, A. Hinoki, E. Brailoiu, A. D. Eckhart, G. D. Frank, and S. Eguchi
Central Role of Gq in the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells
Endocrinology, July 1, 2008; 149(7): 3569 - 3575.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Guilluy, M. Rolli-Derkinderen, L. Loufrani, A. Bourge, D. Henrion, L. Sabourin, G. Loirand, and P. Pacaud
Ste20-Related Kinase SLK Phosphorylates Ser188 of RhoA to Induce Vasodilation in Response to Angiotensin II Type 2 Receptor Activation
Circ. Res., May 23, 2008; 102(10): 1265 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Nakashima, G. D. Frank, H. Shirai, A. Hinoki, S. Higuchi, H. Ohtsu, K. Eguchi, A. Sanjay, M. E. Reyland, P. J. Dempsey, et al.
Novel Role of Protein Kinase C-{delta} Tyr311 Phosphorylation in Vascular Smooth Muscle Cell Hypertrophy by Angiotensin II
Hypertension, February 1, 2008; 51(2): 232 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Baudet
Pathophysiology of heart failure: more bricks in the "crumbling sarcolemmal scaffolding" paradigm?
Cardiovasc Res, February 1, 2005; 65(2): 299 - 301.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.