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Cardiovascular Research 2004 62(1):43-52; doi:10.1016/j.cardiores.2004.01.013
© 2004 by European Society of Cardiology
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Copyright © 2004, European Society of Cardiology

S-nitrosylation: a potential new paradigm in signal transduction

Antonio Martínez-Ruiza,b and Santiago Lamas*,a,b

aCentro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas and Instituto "Reina Sofía" de Investigaciones Nefrológicas, Ramiro de Maeztu, 9, Madrid E-28040, Spain
bFundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Ronda de Poniente, 5, Tres Cantos E-28760, Madrid, Spain

* Corresponding author. Tel.: +34-91-8373112x4302; fax: +34-91-5360432. Email address: slamas{at}cib.csic.es

Much attention has been paid to nitric oxide (NO) research since its discovery as a physiological mediator in the cardiovascular system. In recent years, newer roles have been attributed to this molecule and its close relatives, termed collectively reactive nitrogen species (RNS). These roles relate to different mechanisms of protein modification, among which S-nitrosylation of cysteines has emerged as a potential new paradigm in signal transduction and regulation of protein function. We review here the chemical basis of this modification compared with other protein modifications related to nitric oxide, as well as the kind of specificity we can expect from it. We also review the current methodologies that can be applied to the study of S-nitrosylation and identification of S-nitrosylated proteins in cells, and detail the relevance of this modification in several proteins related to cardiovascular system.

KEYWORDS Signal transduction; Nitric oxide

Time for primary review 23 days


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