Skip Navigation

Cardiovascular Research 2004 62(1):4-6; doi:10.1016/j.cardiores.2004.01.036
© 2004 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Diaz, R. J
Right arrow Articles by Wilson, G. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diaz, R. J
Right arrow Articles by Wilson, G. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004, European Society of Cardiology

Modifying the first minute of reperfusion: potential for myocardial salvage

Roberto J Diaz*,a,b and Gregory J Wilsona,b,c

aDivision of Cardiovascular Research, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
bDepartment of Laboratory Medicine, Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada
cDepartments of Laboratory Medicine and Pathobiology, Physiology and Surgery, University of Toronto, Toronto, ON, Canada

* Corresponding author. Division of Cardiovascular Research, Research Institute, The Hospital for Sick Children, McMaster Building, Rm. 7019C, 555 University Avenue, Toronto, ON, Canada M5G 1X8. Tel.: +1-416-813-8720; fax: +1-416-813-7480. Email address: diazport@sickkids.ca

Received 27 January 2004; accepted 30 January 2004

The first 150 words of the full text of this article appear below.

See article by Kin et al. [1] (pages 74–85) in this issue.

In this issue of Cardiovascular Research, Kin et al. [1] have demonstrated in vivo in rats that following a 30-min index regional myocardial ischemia, protection against reperfusion injury assessed 3 h later through necrosis quantification by tetrazolium staining was achieved by a 1-min duration reperfusion modification protocol that consisted of three cycles of 10 s each of unrestricted reperfusion followed by 10 s of re-occlusion of the same coronary artery subjected to the occlusion causing the index ischemia. This protection, while evident, was substantially less than that achieved by one cycle of preconditioning (5 min of ischemia followed by 10 min of reperfusion immediately preceding the index ischemia). Importantly, delaying the three-cycle (10-s ‘on’/10-s ‘off’) reperfusion modification protocol by 1 min (its duration) failed to protect the myocardium at risk against infarction. Furthermore, doubling the reperfusion modification . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
R. J. Diaz and G. J. Wilson
Studying ischemic preconditioning in isolated cardiomyocyte models
Cardiovasc Res, May 1, 2006; 70(2): 286 - 296.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. Serviddio, N. Di Venosa, A. Federici, D. D'Agostino, T. Rollo, F. Prigigallo, E. Altomare, T. Fiore, and G. Vendemiale
Brief hypoxia before normoxic reperfusion (postconditioning) protects the heart against ischemia-reperfusion injury by preventing mitochondria peroxyde production and glutathione depletion
FASEB J, March 1, 2005; 19(3): 354 - 361.
[Abstract] [Full Text] [PDF]