© 2004 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Mitochondrial permeability transition pore opening during myocardial reperfusion—a target for cardioprotection
Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
* Corresponding author. Tel.: +44-117-928-8592; fax: +44-117-928-8274. a.halestrap{at}bristol.ac.uk
1 Current address: Department of Physiology and Pharmacology, University of Western Ontario, Medical Sciences Building, London, Ontario, Canada N6A 5C1.
Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (MPTP). This transition causes mitochondria to become uncoupled and capable of hydrolysing rather than synthesising ATP. Unrestrained, this will lead to the loss of ionic homeostasis and ultimately necrotic cell death. The functional recovery of the Langendorff-perfused heart from ischaemia inversely correlates with the extent of pore opening, and inhibition of the MPTP provides protection against reperfusion injury. This may be mediated either by a direct interaction with the MPTP [e.g., by Cyclosporin A (CsA) and Sanglifehrin A (SfA)], or indirectly by decreasing calcium loading and reactive oxygen species (ROS; key inducers of pore opening) or lowering intracellular pH. Agents working in this way may include pyruvate, propofol, Na+/H+ antiporter inhibitors, and ischaemic preconditioning (IPC). Mitochondrial KATP channels have been implicated in preconditioning, but our own data suggest that the channel openers and blockers used in these studies work through alternative mechanisms. In addition to its role in necrosis, transient opening of the MPTP may occur and lead to the release of cytochrome c and other proapoptotic molecules that initiate the apoptotic cascade. However, only if subsequent MPTP closure occurs will ATP levels be maintained, ensuring that cell death continues down an apoptotic, rather than a necrotic, pathway.
KEYWORDS Ischaemic preconditioning; Mitochondrial potassium channels; Calcium overload; Reactive oxygen species; Apoptosis
Abbreviations: ANT, adenine nucleotide translocase • BKA, bongkrekic acid • CAT, carboxyatractyloside • CsA, Cyclosporin A • CyP, cyclophilin • DOG, 2-deoxyglucose • EDP, end diastolic pressure • IPC, ischaemic preconditioning • LVDP, left ventricular developed pressure • MPT, mitochondrial permeability transition • MPTP, mitochondrial permeability transition pore • PPIase, peptidyl-prolyl cis–trans isomerase • ROS, reactive oxygen species • SfA, Sanglifehrin A • VAAC, voltage-activated anion channel
Time for primary review 14 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Petrosillo, G. Colantuono, N. Moro, F. M. Ruggiero, E. Tiravanti, N. Di Venosa, T. Fiore, and G. Paradies Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1487 - H1493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Javadov, M. Karmazyn, and N. Escobales Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases J. Pharmacol. Exp. Ther., September 1, 2009; 330(3): 670 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Golomb, A. Nyska, and H. Schwalb Occult Cardiotoxicity--Toxic Effects on Cardiac Ischemic Tolerance Toxicol Pathol, August 1, 2009; 37(5): 572 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gomez, B. Li, N. Mewton, I. Sanchez, C. Piot, M. Elbaz, and M. Ovize Inhibition of mitochondrial permeability transition pore opening: translation to patients Cardiovasc Res, July 15, 2009; 83(2): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kato, M. Akao, M. Matsumoto-Ida, T. Makiyama, M. Iguchi, T. Takeda, S. Shimizu, and T. Kita The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging Cardiovasc Res, July 15, 2009; 83(2): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, M. Ruiz-Meana, and H. M. Piper Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues Cardiovasc Res, July 15, 2009; 83(2): 165 - 168. [Full Text] [PDF]
|
|
|
|
|
|
M. Saotome, H. Katoh, Y. Yaguchi, T. Tanaka, T. Urushida, H. Satoh, and H. Hayashi Transient opening of mitochondrial permeability transition pore by reactive oxygen species protects myocardium from ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H1125 - H1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Atar, P. Petzelbauer, J. Schwitter, K. Huber, B. Rensing, J. D. Kasprzak, C. Butter, L. Grip, P. R. Hansen, T. Suselbeck, et al. Effect of Intravenous FX06 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction: Results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) Trial J. Am. Coll. Cardiol., February 24, 2009; 53(8): 720 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Gustafsson and R. A. Gottlieb Autophagy in Ischemic Heart Disease Circ. Res., January 30, 2009; 104(2): 150 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Zhou, L. Zhang, J. Xi, W. Tian, and Z. Xu Ethanol Prevents Oxidant-Induced Mitochondrial Permeability Transition Pore Opening in Cardiac Cells Alcohol Alcohol., January 1, 2009; 44(1): 20 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, I. Barba, V. Hernando, and D. Garcia-Dorado Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium Cardiovasc Res, January 1, 2009; 81(1): 116 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Garciarena, C. I. Caldiz, M. V. Correa, G. R. Schinella, S. M. Mosca, G. E. Chiappe de Cingolani, H. E. Cingolani, and I. L. Ennis Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action J Appl Physiol, December 1, 2008; 105(6): 1706 - 1713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lopez, A. Rodriguez-Sinovas, L. Agullo, J. Inserte, A. Cabestrero, and D. Garcia-Dorado Acidic reoxygenation protects against endothelial dysfunction in rat aortic rings submitted to simulated ischemia Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2409 - H2416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. West, G. Rokosh, D. Obal, M. Velayutham, Y.-T. Xuan, B. G. Hill, R. J. Keith, J. Schrader, Y. Guo, D. J. Conklin, et al. Cardiac Myocyte-Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition Circulation, November 4, 2008; 118(19): 1970 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Das, R. Wong, N. Rajapakse, E. Murphy, and C. Steenbergen Glycogen Synthase Kinase 3 Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates Voltage-Dependent Anion Channel Phosphorylation Circ. Res., October 24, 2008; 103(9): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Leshnower, S. Kanemoto, M. Matsubara, H. Sakamoto, R. Hinmon, J. H. Gorman III, and R. C. Gorman Cyclosporine Preserves Mitochondrial Morphology After Myocardial Ischemia/Reperfusion Independent of Calcineurin Inhibition Ann. Thorac. Surg., October 1, 2008; 86(4): 1286 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanno and T. Miura Adenine nucleotide translocator, a mitochondrial carrier protein, and fate of cardiomyocytes after ischaemia/reperfusion Cardiovasc Res, October 1, 2008; 80(1): 1 - 2. [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. C. Leung, P. Varanyuwatana, and A. P. Halestrap The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition J. Biol. Chem., September 26, 2008; 283(39): 26312 - 26323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ban, A. J. Cooper, S. Samuel, A. Bhatti, M. Patel, S. Izumo, J. M. Penninger, P. H. Backx, G. Y. Oudit, and R. G. Tsushima Phosphatidylinositol 3-Kinase {gamma} Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning Circ. Res., September 12, 2008; 103(6): 643 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Pagel, J. G. Krolikowski, P. F. Pratt Jr, Y. H. Shim, J. Amour, D. C. Warltier, and D. Weihrauch Inhibition of Glycogen Synthase Kinase or the Apoptotic Protein p53 Lowers the Threshold of Helium Cardioprotection In Vivo: The Role of Mitochondrial Permeability Transition Anesth. Analg., September 1, 2008; 107(3): 769 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chanoit, S. Lee, J. Xi, M. Zhu, R. A. McIntosh, R. A. Mueller, E. A. Norfleet, and Z. Xu Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3{beta} Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1227 - H1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kobayashi, S. Minatoguchi, S. Yasuda, N. Bao, I. Kawamura, M. Iwasa, T. Yamaki, S. Sumi, Y. Misao, H. Ushikoshi, et al. Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair Cardiovasc Res, September 1, 2008; 79(4): 611 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. McAllister, H. Ashrafpour, N. Cahoon, N. Huang, M. A. Moses, P. C. Neligan, C. R. Forrest, J. E. Lipa, and C. Y. Pang Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R681 - R689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishino, I. G. Webb, S. M. Davidson, A. I. Ahmed, J. E. Clark, S. Jacquet, A. M. Shah, T. Miura, D. M. Yellon, M. Avkiran, et al. Glycogen Synthase Kinase-3 Inactivation Is Not Required for Ischemic Preconditioning or Postconditioning in the Mouse Circ. Res., August 1, 2008; 103(3): 307 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ussher and G. D. Lopaschuk The malonyl CoA axis as a potential target for treating ischaemic heart disease Cardiovasc Res, July 15, 2008; 79(2): 259 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. N. Obame, C. Plin-Mercier, R. Assaly, R. Zini, J. L. Dubois-Rande, A. Berdeaux, and D. Morin Cardioprotective Effect of Morphine and a Blocker of Glycogen Synthase Kinase 3{beta}, SB216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via Inhibition of the Mitochondrial Permeability Transition Pore J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 252 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gomez, M. Paillard, H. Thibault, G. Derumeaux, and M. Ovize Inhibition of GSK3{beta} by Postconditioning Is Required to Prevent Opening of the Mitochondrial Permeability Transition Pore During Reperfusion Circulation, May 27, 2008; 117(21): 2761 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Clarke, I. Khaliulin, M. Das, J. E. Parker, K. J. Heesom, and A. P. Halestrap Inhibition of Mitochondrial Permeability Transition Pore Opening by Ischemic Preconditioning Is Probably Mediated by Reduction of Oxidative Stress Rather Than Mitochondrial Protein Phosphorylation Circ. Res., May 9, 2008; 102(9): 1082 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Jones, N. E. Zachara, G. A. Ngoh, B. G. Hill, Y. Teshima, A. Bhatnagar, G. W. Hart, and E. Marban Cardioprotection by N-Acetylglucosamine Linkage to Cellular Proteins Circulation, March 4, 2008; 117(9): 1172 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Marinovic, M. Ljubkovic, A. Stadnicka, Z. J. Bosnjak, and M. Bienengraeber Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connection Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1317 - H1325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, I. Barba, V. Hernando, A. Abellan, M. Ruiz-Meana, A. Rodriguez-Sinovas, and D. Garcia-Dorado Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage Cardiovasc Res, March 1, 2008; 77(4): 782 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ricci, V. Pastukh, J. Leonard, J. Turrens, G. Wilson, D. Schaffer, and S. W. Schaffer Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis Am J Physiol Cell Physiol, February 1, 2008; 294(2): C413 - C422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Gustafsson and R. A. Gottlieb Heart mitochondria: gates of life and death Cardiovasc Res, January 15, 2008; 77(2): 334 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ruiz-Meana, A. Rodriguez-Sinovas, A. Cabestrero, K. Boengler, G. Heusch, and D. Garcia-Dorado Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury Cardiovasc Res, January 15, 2008; 77(2): 325 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Piper, Y. Abdallah, S. Kasseckert, and K.-D. Schluter Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury Cardiovasc Res, January 15, 2008; 77(2): 234 - 236. [Full Text] [PDF]
|
|
|
|
|
|
L. Argaud, O. Gateau-Roesch, L. Augeul, E. Couture-Lepetit, J. Loufouat, L. Gomez, D. Robert, and M. Ovize Increased mitochondrial calcium coexists with decreased reperfusion injury in postconditioned (but not preconditioned) hearts Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H386 - H391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Rodrigo and N. J. Samani Ischemic preconditioning of the whole heart confers protection on subsequently isolated ventricular myocytes Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H524 - H531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Jin, R. Whittaker, M. S. Glassy, S. B. Barlow, R. A. Gottlieb, and C. C. Glembotski Localization of phosphorylated {alpha}B-crystallin to heart mitochondria during ischemia-reperfusion Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H337 - H344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jahangir, S. Sagar, and A. Terzic Aging and cardioprotection J Appl Physiol, December 1, 2007; 103(6): 2120 - 2128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferdinandy, R. Schulz, and G. F. Baxter Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning Pharmacol. Rev., December 1, 2007; 59(4): 418 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Hadzimichalis, S. S. Baliga, R. Golfetti, K. M. Jaques, B. L. Firestein, and G. F. Merrill Acetaminophen-mediated cardioprotection via inhibition of the mitochondrial permeability transition pore-induced apoptotic pathway Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3348 - H3355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Jakobsen, S. Muller, E. Aarsaether, T. Steensrud, and D. G. Sorlie Adenosine instead of supranormal potassium in cardioplegic solution improves cardioprotection Eur. J. Cardiothorac. Surg., September 1, 2007; 32(3): 493 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Townsend, S. M. Davidson, S. J. Clarke, I. Khaliulin, C. J. Carroll, T. M. Scarabelli, R. A. Knight, A. Stephanou, D. S. Latchman, and A. P. Halestrap Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H928 - H938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Baines The mitochondrial permeability transition pore as a target of cardioprotective signaling Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H903 - H904. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Khaliulin, S. J. Clarke, H. Lin, J. Parker, M.-S. Suleiman, and A. P. Halestrap Temperature preconditioning of isolated rat hearts - a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore J. Physiol., June 15, 2007; 581(3): 1147 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Davidson and M. R. Duchen Endothelial Mitochondria: Contributing to Vascular Function and Disease Circ. Res., April 27, 2007; 100(8): 1128 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Madamanchi and M. S. Runge Mitochondrial Dysfunction in Atherosclerosis Circ. Res., March 2, 2007; 100(4): 460 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, C. Zaragoza, and W. Holman Sodium-Hydrogen Exchange Inhibition and {beta}-Blockade Additively Decrease Infarct Size Ann. Thorac. Surg., March 1, 2007; 83(3): 1121 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Fruehauf and F. L. Meyskens Jr. Reactive Oxygen Species: A Breath of Life or Death? Clin. Cancer Res., February 1, 2007; 13(3): 789 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Satrustegui, B. Pardo, and A. del Arco Mitochondrial Transporters as Novel Targets for Intracellular Calcium Signaling Physiol Rev, January 1, 2007; 87(1): 29 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kroemer, L. Galluzzi, and C. Brenner Mitochondrial Membrane Permeabilization in Cell Death Physiol Rev, January 1, 2007; 87(1): 99 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, A. K. S. Camara, D. F. Stowe, C. L. Hoppel, and E. J. Lesnefsky Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion Am J Physiol Cell Physiol, January 1, 2007; 292(1): C137 - C147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Bell, J. E. Clark, D. J. Hearse, and M. J. Shattock Reperfusion kinase phosphorylation is essential but not sufficient in the mediation of pharmacological preconditioning: Characterisation in the bi-phasic profile of early and late protection Cardiovasc Res, January 1, 2007; 73(1): 153 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shalbuyeva, T. Brustovetsky, A. Bolshakov, and N. Brustovetsky Calcium-dependent Spontaneously Reversible Remodeling of Brain Mitochondria J. Biol. Chem., December 8, 2006; 281(49): 37547 - 37558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Budas, A. Sukhodub, D. R. Alessi, and A. Jovanovic 3'phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium FASEB J, December 1, 2006; 20(14): 2556 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Boengler, R Schulz, and G Heusch Connexin 43 signalling and cardioprotection Heart, December 1, 2006; 92(12): 1724 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wall, J. Wei, M. Ly, P. Belmont, J. J. Martindale, D. Tran, J. Sun, W. J. Chen, W. Yu, P. Oeller, et al. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6 Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2462 - H2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Sack Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance Cardiovasc Res, November 1, 2006; 72(2): 210 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsumoto-Ida, M. Akao, T. Takeda, M. Kato, and T. Kita Real-Time 2-Photon Imaging of Mitochondrial Function in Perfused Rat Hearts Subjected to Ischemia/Reperfusion Circulation, October 3, 2006; 114(14): 1497 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nishihara, T. Miura, T. Miki, J. Sakamoto, M. Tanno, H. Kobayashi, Y. Ikeda, K. Ohori, A. Takahashi, and K. Shimamoto Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3beta Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H748 - H755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Larche, S. Lancel, S. M. Hassoun, R. Favory, B. Decoster, P. Marchetti, C. Chopin, and R. Neviere Inhibition of Mitochondrial Permeability Transition Prevents Sepsis-Induced Myocardial Dysfunction and Mortality J. Am. Coll. Cardiol., July 18, 2006; 48(2): 377 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Halestrap Mitochondria and Preconditioning: A Connexin Connection? Circ. Res., July 7, 2006; 99(1): 10 - 12. [Full Text] [PDF]
|
|
|
|
|
|
A. Rodriguez-Sinovas, K. Boengler, A. Cabestrero, P. Gres, M. Morente, M. Ruiz-Meana, I. Konietzka, E. Miro, A. Totzeck, G. Heusch, et al. Translocation of Connexin 43 to the Inner Mitochondrial Membrane of Cardiomyocytes Through the Heat Shock Protein 90-Dependent TOM Pathway and Its Importance for Cardioprotection Circ. Res., July 7, 2006; 99(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-S. Park, H. Zhao, Y. Jang, R. A. Mueller, and Z. Xu N6-(3-Iodobenzyl)-adenosine-5'-N-methylcarboxamide Confers Cardioprotection at Reperfusion by Inhibiting Mitochondrial Permeability Transition Pore Opening via Glycogen Synthase Kinase 3beta J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takeda, M. Akao, M. Matsumoto-Ida, M. Kato, H. Takenaka, Y. Kihara, T. Kume, A. Akaike, and T. Kita Serofendic Acid, a Novel Substance Extracted From Fetal Calf Serum, Protects Against Oxidative Stress in Neonatal Rat Cardiac Myocytes J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1882 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Di Lisa and P. Bernardi Mitochondria and ischemia-reperfusion injury of the heart: Fixing a hole Cardiovasc Res, May 1, 2006; 70(2): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Zhao and J. Vinten-Johansen Postconditioning: Reduction of reperfusion-induced injury Cardiovasc Res, May 1, 2006; 70(2): 200 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Gateau-Roesch, L. Argaud, and M. Ovize Mitochondrial permeability transition pore and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 264 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, A. Rodriguez-Sinovas, M. Ruiz-Meana, J. Inserte, L. Agullo, and A. Cabestrero The end-effectors of preconditioning protection against myocardial cell death secondary to ischemia-reperfusion Cardiovasc Res, May 1, 2006; 70(2): 274 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kyoi, H. Otani, A. Hamano, S. Matsuhisa, Y. Akita, H. Fujiwara, R. Hattori, H. Imamura, H. Kamihata, and T. Iwasaka Dystrophin is a possible end-target of ischemic preconditioning against cardiomyocyte oncosis during the early phase of reperfusion Cardiovasc Res, May 1, 2006; 70(2): 354 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, D. Garcia-Dorado, V. Hernando, I. Barba, and J. Soler-Soler Ischemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion Cardiovasc Res, May 1, 2006; 70(2): 364 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Mozaffari, C. Patel, and S. W. Schaffer Mechanisms Underlying Afterload-Induced Exacerbation of Myocardial Infarct Size: Role of T-Type Ca2+ Channel Hypertension, May 1, 2006; 47(5): 912 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Bovill Intravenous Anesthesia for the Patient with Left Ventricular Dysfunction Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 43 - 48. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Schwartz and C. J. Lagranha Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1011 - H1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Petrosillo, N. Di Venosa, M. Pistolese, G. Casanova, E. Tiravanti, G. Colantuono, A. Federici, G. Paradies, and F. M. Ruggiero Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin FASEB J, February 1, 2006; 20(2): 269 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vinten-Johansen, D. M. Yellon, and L. H. Opie Postconditioning: A Simple, Clinically Applicable Procedure to Improve Revascularization in Acute Myocardial Infarction Circulation, October 4, 2005; 112(14): 2085 - 2088. [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, D. Garcia-Dorado, V. Hernando, and J. Soler-Soler Calpain-Mediated Impairment of Na+/K+-ATPase Activity During Early Reperfusion Contributes to Cell Death After Myocardial Ischemia Circ. Res., September 2, 2005; 97(5): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Boengler, G. Dodoni, A. Rodriguez-Sinovas, A. Cabestrero, M. Ruiz-Meana, P. Gres, I. Konietzka, C. Lopez-Iglesias, D. Garcia-Dorado, F. Di Lisa, et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning Cardiovasc Res, August 1, 2005; 67(2): 234 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Rodrigo and N. B. Standen Role of mitochondrial re-energization and Ca2+ influx in reperfusion injury of metabolically inhibited cardiac myocytes Cardiovasc Res, August 1, 2005; 67(2): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. van Beek-Harmsen and W. J. van der Laarse Immunohistochemical Determination of Cytosolic Cytochrome c Concentration in Cardiomyocytes J. Histochem. Cytochem., July 1, 2005; 53(7): 803 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Menze, K. Hutchinson, S. M. Laborde, and S. C. Hand Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R68 - R76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T.F. Facundo, A. J. Kowaltowski, L. Argaud, O. Gateau-Roesch, O. Raisky, J. Loufouat, M. Ovize, and D. Robert Letter Regarding Article by Argaud et al, "Postconditioning Inhibits Mitochondrial Permeability Transition" Circulation, June 21, 2005; 111(24): e442 - e442. [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. H. Lim, A. P. Halestrap, G. D. Angelini, and M.-S. Suleiman Propofol Is Cardioprotective in a Clinically Relevant Model of Normothermic Blood Cardioplegic Arrest and Cardiopulmonary Bypass Experimental Biology and Medicine, June 1, 2005; 230(6): 413 - 420. [Abstract] [Full Text] [PDF]
|
|