© 2004 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
The first minutes of reperfusion: a window of opportunity for cardioprotection
Physiologisches Institut, Justus-Liebig-Universität, Aulweg 129, D-35392 Giessen, Germany
* Corresponding author. Tel.: +49-641-9947241; fax: +49-641-9947239. michael.piper{at}physiologie.med.uni-giessen.de
During the past decade, the understanding has grown that control of the conditions of reperfusion is critical for salvaging ischemic–reperfused myocardium. The first few minutes of reperfusion constitute a critical phase, as here lethal tissue injury in addition to that already developed during ischemia may be initiated. The identification of the mechanisms of reperfusion-induced cell death opens a new window of opportunity for cardioprotection in the clinic. Development of cardiomyocyte hypercontracture is a predominant feature of reperfusion injury. We and others have shown that control of hypercontracture in reperfusion reduces the extent of tissue injury. On the cellular level, it was shown that reperfusion-induced hypercontracture might either originate from a rigor-type mechanism, when energy recovery proceeds very slowly, or from Ca2+ overload, when energy recovery is rapid but cytosolic Ca2+ load is high. These two mechanisms can be influenced by various interventions that either connect with cytosolic Ca2+ control or myofibrillar Ca2+ sensitivity or with mitochondrial energy production. These experimental approaches will hopefully lead to novel strategies for clinical cardioprotection during the early phase of reperfusion.
KEYWORDS Calcium; Cardioprotection; Hypercontracture; Ischemia; Reperfusion
Time for primary review 15 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Miki, T. Miura, H. Hotta, M. Tanno, T. Yano, T. Sato, Y. Terashima, A. Takada, S. Ishikawa, and K. Shimamoto Endoplasmic Reticulum Stress in Diabetic Hearts Abolishes Erythropoietin-Induced Myocardial Protection by Impairment of Phospho-Glycogen Synthase Kinase-3{beta}-Mediated Suppression of Mitochondrial Permeability Transition Diabetes, December 1, 2009; 58(12): 2863 - 2872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gomez, B. Li, N. Mewton, I. Sanchez, C. Piot, M. Elbaz, and M. Ovize Inhibition of mitochondrial permeability transition pore opening: translation to patients Cardiovasc Res, July 15, 2009; 83(2): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, J. A. Barrabes, V. Hernando, and D. Garcia-Dorado Orphan targets for reperfusion injury Cardiovasc Res, July 15, 2009; 83(2): 169 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. O'Brien, S. E. Howlett, H. J. Burton, S. B. O'Blenes, D. S. Litz, and C. L. H. Friesen Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T. Ann. Thorac. Surg., May 1, 2009; 87(5): 1517 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Whittaker, M. S. Glassy, N. Gude, M. A. Sussman, R. A. Gottlieb, and C. C. Glembotski Kinetics of the translocation and phosphorylation of {alpha}B-crystallin in mouse heart mitochondria during ex vivo ischemia Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1633 - H1642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Abdel-Rahman, P. Risteski, K. Tizi, S. Kerscher, S. Bejati, K. Zwicker, M. Scholz, U. Brandt, and A. Moritz Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia-reperfusion injury after cardioplegic arrest in a porcine model J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 978 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Solaro Maintaining cooperation among cardiac myofilament proteins through thick and thin J. Physiol., January 1, 2009; 587(1): 3 - 3. [Full Text] [PDF]
|
|
|
|
|
|
J. D. McCully, D. B. Cowan, C. A. Pacak, I. K. Toumpoulis, H. Dayalan, and S. Levitsky Injection of isolated mitochondria during early reperfusion for cardioprotection Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H94 - H105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Takahashi Anoxic cell core can promote necrotic cell death in cardiomyocytes at physiological extracellular PO2 Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2507 - H2515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Opie Metabolic Management of Acute Myocardial Infarction Comes to the Fore and Extends Beyond Control of Hyperglycemia Circulation, April 29, 2008; 117(17): 2172 - 2177. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Shan, R. B. Marchase, and J. C. Chatham Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes Am J Physiol Cell Physiol, March 1, 2008; 294(3): C833 - C841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, I. Barba, V. Hernando, A. Abellan, M. Ruiz-Meana, A. Rodriguez-Sinovas, and D. Garcia-Dorado Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage Cardiovasc Res, March 1, 2008; 77(4): 782 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Piper, Y. Abdallah, S. Kasseckert, and K.-D. Schluter Sarcoplasmic reticulum-mitochondrial interaction in the mechanism of acute reperfusion injury Cardiovasc Res, January 15, 2008; 77(2): 234 - 236. [Full Text] [PDF]
|
|
|
|
|
|
R. Jiang, A. Zatta, H. Kin, N. Wang, J. G. Reeves, J. Mykytenko, J. Deneve, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2845 - H2852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Deyhimy, N. W. Fleming, I. G. Brodkin, and H. Liu Anesthetic Preconditioning Combined with Postconditioning Offers No Additional Benefit Over Preconditioning or Postconditioning Alone Anesth. Analg., August 1, 2007; 105(2): 316 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanno and T. Miura Protecting ischemic hearts by modulation of SR calcium handling Cardiovasc Res, August 1, 2007; 75(3): 453 - 454. [Full Text] [PDF]
|
|
|
|
|
|
M. T. Dirksen, G. J. Laarman, M. L. Simoons, and D. J.G.M. Duncker Reperfusion injury in humans: A review of clinical trials on reperfusion injury inhibitory strategies Cardiovasc Res, June 1, 2007; 74(3): 343 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vila-Petroff, M. A. Salas, M. Said, C. A. Valverde, L. Sapia, E. Portiansky, R. J. Hajjar, E. G. Kranias, C. Mundina-Weilenmann, and A. Mattiazzi CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury Cardiovasc Res, March 1, 2007; 73(4): 689 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lanoye, P. Segers, V. Tchana-Sato, S. Rolin, J.-M. Dogne, A. Ghuysen, B. Lambermont, J. Hanson, T. Desaive, P. Verdonck, et al. Cardiovascular Control: Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion Exp Physiol, January 1, 2007; 92(1): 127 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rodriguez-Sinovas, K. Boengler, A. Cabestrero, P. Gres, M. Morente, M. Ruiz-Meana, I. Konietzka, E. Miro, A. Totzeck, G. Heusch, et al. Translocation of Connexin 43 to the Inner Mitochondrial Membrane of Cardiomyocytes Through the Heat Shock Protein 90-Dependent TOM Pathway and Its Importance for Cardioprotection Circ. Res., July 7, 2006; 99(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Piper, S. Kasseckert, and Y. Abdallah The sarcoplasmic reticulum as the primary target of reperfusion protection Cardiovasc Res, May 1, 2006; 70(2): 170 - 173. [Full Text] [PDF]
|
|
|
|
|
|
E. R. Gross and G. J. Gross Ligand triggers of classical preconditioning and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 212 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Gateau-Roesch, L. Argaud, and M. Ovize Mitochondrial permeability transition pore and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 264 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, A. Rodriguez-Sinovas, M. Ruiz-Meana, J. Inserte, L. Agullo, and A. Cabestrero The end-effectors of preconditioning protection against myocardial cell death secondary to ischemia-reperfusion Cardiovasc Res, May 1, 2006; 70(2): 274 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Abdallah, A. Gkatzoflia, D. Gligorievski, S. Kasseckert, G. Euler, K.-D. Schluter, M. Schafer, H.-M. Piper, and C. Schafer Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca2+ storage Cardiovasc Res, May 1, 2006; 70(2): 346 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, D. Garcia-Dorado, V. Hernando, I. Barba, and J. Soler-Soler Ischemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion Cardiovasc Res, May 1, 2006; 70(2): 364 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, X.-Y. Lu, J. Li, J.-D. Fu, Z.-N. Zhou, and H.-T. Yang Intermittent hypoxia protects cardiomyocytes against ischemia-reperfusion injury-induced alterations in Ca2+ homeostasis and contraction via the sarcoplasmic reticulum and Na+/Ca2+ exchange mechanisms Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1221 - C1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Montana and J. T. Littleton Expression Profiling of a Hypercontraction-induced Myopathy in Drosophila Suggests a Compensatory Cytoskeletal Remodeling Response J. Biol. Chem., March 24, 2006; 281(12): 8100 - 8109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Schwartz and C. J. Lagranha Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1011 - H1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Smart, M. H. Mojet, D. S. Latchman, M. S. Marber, M. R. Duchen, and R. J. Heads IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes Cardiovasc Res, January 1, 2006; 69(1): 164 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamura, C. Steenbergen, and E. Murphy Protein kinase C and preconditioning: role of the sarcoplasmic reticulum Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2484 - H2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vinten-Johansen, D. M. Yellon, and L. H. Opie Postconditioning: A Simple, Clinically Applicable Procedure to Improve Revascularization in Acute Myocardial Infarction Circulation, October 4, 2005; 112(14): 2085 - 2088. [Full Text] [PDF]
|
|
|
|
|
|
J. Inserte, D. Garcia-Dorado, V. Hernando, and J. Soler-Soler Calpain-Mediated Impairment of Na+/K+-ATPase Activity During Early Reperfusion Contributes to Cell Death After Myocardial Ischemia Circ. Res., September 2, 2005; 97(5): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Rodrigo and N. B. Standen Role of mitochondrial re-energization and Ca2+ influx in reperfusion injury of metabolically inhibited cardiac myocytes Cardiovasc Res, August 1, 2005; 67(2): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tsang, D. J. Hausenloy, and D. M. Yellon Myocardial postconditioning: reperfusion injury revisited Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H2 - H7. [Full Text] [PDF]
|
|
|
|
|
|
A. Robinet, G. Hoizey, and H. Millart PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of {beta}1-adrenergic preconditioning Cardiovasc Res, June 1, 2005; 66(3): 530 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schulz A new paradigm: cross talk of protein kinases during reperfusion saves life! Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H1 - H2. [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado, K.-D. Schluter, E. A. Martinson, and H. M. Piper Which papers are most interesting to the readers of Cardiovascular Research? Information from download monitoring Cardiovasc Res, January 1, 2005; 65(1): 1 - 5. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch Postconditioning: Old wine in a new bottle? J. Am. Coll. Cardiol., September 1, 2004; 44(5): 1111 - 1112. [Full Text] [PDF]
|
|
|
|
|
|
D. Garcia-Dorado Myocardial reperfusion injury: a new view Cardiovasc Res, February 15, 2004; 61(3): 363 - 364. [Full Text] [PDF]
|
|