© 2004 by European Society of Cardiology
Copyright © 2004, European Society of Cardiology
Growth hormone-releasing peptides and the heart: secretagogues or cardioprotectors?
Department of Physiology and Biophysics, University of Alabama Birmingham, 1918 University Blvd., MCLM-986, Birmingham, AL 35294-0005, USA
* Tel.: +1-205-934-5742; fax: +1-205-975-9028. lucchesi@physiology.uab.edu
Received 10 November 2003; accepted 14 November 2003
| The first 10% of the full text of this article appears below. |
See article by Iwase et al. [13] in this issue.
Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are multifunctional hormones with potent cardiotropic effects in prenatal and postnatal cardiac development. Evidence from animal and clinical studies has documented the beneficial effects of the GH-IGF-1 axis on cardiac hypertrophy and contractile function under conditions of GH deficiency, cardiomyopathy and ischemia reperfusion injury [1]. In rats with heart failure due to myocardial infarction, GH and IGF-1 increased cardiac output
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