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Cardiovascular Research 2003 60(3):702-703; doi:10.1016/j.cardiores.2003.10.001
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Cardiovascular effects of sildenafil in experimental ischemia–reperfusion (reply to "Sildenafil-induced cardioprotection in rabbits, by Kukreja, R.C., Ockaili, R., Salloum, F., Xi, L.")

Thorsten Reffelmann and Robert A Kloner*

The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017-2395, USA

*Corresponding author. Tel.: +1-213-977-4050; fax: +1-213-977-4107. Email address: rkloner@goodsam.org

Received 24 September 2003; accepted 1 October 2003

The first 10% of the full text of this article appears below.

In their letter to the editor, Kukreja, Ockaili, Salloum and Xi comment on our recently published study in which intravenous application of 1.45 or 0.7 mg/kg sildenafil 30 min prior to coronary artery occlusion did not reduce myocardial infarct size in an experimental rabbit model of 30 min ischemia followed by 180 min of reperfusion [1]. Since our results contrast with a recent investigation by this research group [2] that described pronounced infarct size reduction after pretreatment with sildenafil in a very similar model, the authors . . . [Full Text of this Article]


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