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Cardiovascular Research 2003 60(3):700-701; doi:10.1016/j.cardiores.2003.10.002
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Sildenafil-induced cardioprotection in rabbits

Rakesh C Kukreja*, Ramzi Ockaili, Fadi Salloum and Lei Xi

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Medical Center, 1101 East Marshall Street, Richmond, VA 23298-0281, USA

*Corresponding author. Tel.: +1-804-828-0389; fax: +1-804-828-8700. Email address: rakesh@hsc.vcu.edu

Received 9 September 2003; revised 11 September 2003; accepted 1 October 2003

The first 10% of the full text of this article appears below.

In the August issue of this journal, Reffelmann and Kloner [1] reported the effects of sildenafil (Viagra) on myocardial infarct size following ischemia–reperfusion (I–R). These authors showed that pretreatment with 0.7 or 1.45 mg/kg of sildenafil prior to ischemia resulted in no protection against myocardial infarction. These findings are in contrast with a previous study from our laboratory [2] that demonstrated a significant reduction of infarct size in the rabbits . . . [Full Text of this Article]


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