Skip Navigation

Cardiovascular Research 2003 60(1):58-67; doi:10.1016/S0008-6363(03)00348-1
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by de Kleijn, D.
Right arrow Articles by Pasterkamp, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Kleijn, D.
Right arrow Articles by Pasterkamp, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Toll-like receptors in cardiovascular diseases

Dominique de Kleijna,b,* and Gerard Pasterkampa

aExperimental Cardiology Laboratory, University Medical Center (G02 523), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
bInteruniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands

*Corresponding author. Tel.: +31-30-250-7155; fax: +31-30-252-2693. Email address: d.dekleijn{at}hli.azu.nl

The Toll-like receptor family recognizes mostly exogenous ligands like bacterial lipopolysaccharides or DNA and activates the inflammatory cell. Evidence is accumulating that these Toll-like receptors are important in cardiovascular pathologies. Recently, expression of Toll-like receptors in arterial and myocardial cells has been shown and mouse knockout and human studies on polymorphisms point to a role of Toll-like receptor 4 in neointima formation and atherosclerosis. It is now becoming clear that these receptors not only serve as receptors for pathogen-associated molecular patterns but are also involved in the initiation and progression of cardiovascular pathologies.

KEYWORDS Atherosclerosis; Receptors; Infection/Inflammation; Arteries; Immunology

Time for primary review 36 days.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
V. Ruppert, T. Meyer, S. Pankuweit, E. Moller, R. C. Funck, W. Grimm, B. Maisch, and German Heart Failure Network
Gene expression profiling from endomyocardial biopsy tissue allows distinction between subentities of dilated cardiomyopathy.
J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 360 - 369.e1.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
V. M. Miller and S. P. Duckles
Vascular Actions of Estrogens: Functional Implications
Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Takahashi
Toll-like receptors and myocardial contractile dysfunction
Cardiovasc Res, April 1, 2008; 78(1): 3 - 4.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Erridge, C. M. Spickett, and D. J. Webb
Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2
Cardiovasc Res, January 1, 2007; 73(1): 181 - 189.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.