© 2003 by European Society of Cardiology
Copyright © 2003, European Society of Cardiology
Of mice and men, rats and atherosclerosis
Department of Surgery, University of Alberta, 275 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2
jim.russell@ualberta.ca
* Tel.: +1-780-492-6359; fax: +1-780-492-1308.
Received 16 July 2003; revised 17 July 2003; accepted 20 July 2003
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See article by Lyngdorf et al. [10] (pages 854–862) in this issue.
In less than 100 years, biology and medicine have been transformed by the effects of research that has eclipsed that of the 19th century in chemistry and that of the early half of the 20th century in physics. Whereas clinical research on human subjects has been important at the level of the application of knowledge at the bedside, the fundamental discoveries have been the result of basic science. Since the days of Harvey [1], real advances in the biomedical sciences have depended critically on the use of animals as models of human physiology, pathophysiology, and metabolism. Current animal models constitute technology that has been derived from scientific advances that, in turn,