Skip Navigation

Cardiovascular Research 2003 58(3):575-581; doi:10.1016/S0008-6363(03)00285-2
© 2003 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Taylor, R. P
Right arrow Articles by Starnes, J. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, R. P
Right arrow Articles by Starnes, J. W
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2003, European Society of Cardiology

Effect of exercise training on the ability of the rat heart to tolerate hydrogen peroxide

Ryan P Taylor, Joseph T Ciccolo and Joseph W Starnes*

Cardiac Metabolism Laboratory, Department of Kinesiology and Health Education, 222 Bellmont Hall, The University of Texas at Austin, Austin, TX 78712, USA

jstarnes{at}mail.utexas.edu

* Corresponding author. Tel.: +1-512-471-4405; fax: +1-512-471-0946.

Objective: The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H2O2)-induced damage. Methods: Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6° grade, 5 days/week). Isolated perfused working hearts from exercise trained (ET, n = 8) and sedentary (SED, n = 10) animals were perfused with 150 µM H2O2. Results: Pre-H2O2 baseline values for cardiac external work (COxSP), coronary flow (CF), and lactate dehydrogenase (LDH) release were similar between groups. At 5 min of H2O2, COxSP was unchanged from baseline but CF was increased 30% in SED and 46% in ET (P<0.05 vs. SED). COxSP began to decline similarly thereafter in both groups, dropping to 20% of baseline at 20 min. CF in ET remained higher than SED throughout (P<0.05). LDH leakage remained near baseline during the first 15 min of H2O2 exposure, but was elevated (P<0.05) 72% in SED and 40% in ET after 20 min, and was 2.2-fold greater in SED than ET (P<0.05) after 25 min. Heat shock protein 70 was 2.1-fold greater in ET than SED (P<0.05), but ET did not change catalase and glutathione peroxidase. Conclusions: The results of this study indicate that chronic moderate exercise will enhance coronary flow and attenuate the development of myocardial injury when exposed to H2O2, but will not affect H2O2-induced decrease in pump function.

KEYWORDS Ventricular function; Vasoconstriction/dilation; Free radicals; Preconditioning; Hemodynamics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Integr Cancer TherHome page
K. Y. Wonders, D. S. Hydock, C. M. Schneider, and R. Hayward
Acute Exercise Protects Against Doxorubicin Cardiotoxicity
Integr Cancer Ther, September 1, 2008; 7(3): 147 - 154.
[Abstract] [PDF]

Home page
 FASEB J.Home page
J. P. French, K. L. Hamilton, J. C. Quindry, Y. Lee, P. A. Upchurch, and S. K. Powers
Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpain
FASEB J, August 1, 2008; 22(8): 2862 - 2871.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. French, J. C. Quindry, D. J. Falk, J. L. Staib, Y. Lee, K. K. W. Wang, and S. K. Powers
Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition
Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H128 - H136.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. W. Starnes, A. M. Choilawala, R. P. Taylor, M. J. Nelson, and M. D. Delp
Myocardial Heat Shock Protein 70 Expression in Young and Old Rats After Identical Exercise Programs
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 963 - 969.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. J. Chicco, C. M. Schneider, and R. Hayward
Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R424 - R431.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.