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Cardiovascular Research 2003 57(1):1-4; doi:10.1016/S0008-6363(02)00740-X
© 2003 by European Society of Cardiology
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Copyright © 2003, European Society of Cardiology

Sex, drugs and arrhythmia: are gender differences in risk of torsades de pointes simply a matter of testosterone?

Andrew F. James* and Jules C. Hancox

Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK

* Corresponding author. Tel.: +44-117-928-9187; fax: +44-117-928-8923.

Received 14 October 2002; accepted 21 October 2002

The first 150 words of the full text of this article appear below.

See article by Liu et al. [4] (pages 28–36) in this issue.

As highlighted by a recent ‘Spotlight’ issue of Cardiovascular Research [1], the existence of major differences between men and women in the function and pathophysiology of the cardiovascular system implicates the need for gender-specific optimisation of patient treatment. One key gender difference resides in the electrocardiogram: it has long been known that women have higher resting heart rates than men, but that the rate-corrected QT interval (QTc) is longer in women (by 2–6%) [2,3]. As will be discussed below, this difference is an important factor in sex-linked differences in pro-arrhythmic risk, and its basis is the subject of an article in this edition of the journal by Liu et al. [4].

Women are at significantly greater risk than men of developing the potentially lethal ventricular tachyarrhythmia torsades de pointes in response to certain drugs that . . . [Full Text of this Article]


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