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Cardiovascular Research 2002 56(3):487-488; doi:10.1016/S0008-6363(02)00670-3
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Nitric oxide and angiogenic activity of endothelial cells: direct or VEGF-dependent effect?

Józef Dulaka,* and Alicja Józkowiczb,c

aDepartment of Cell Biochemistry, Institute of Molecular Biology and Biotechnology, Jagiellonian University, Kraków, Poland
bLaboratory of Molecular Genetics and Genetic Engineering, Institute of Molecular Biology and Biotechnology, Jagiellonian University, Kraków, Poland
cDepartment of Vascular Surgery, University of Vienna, Vienna, Austria

jdulak@mol.uj.edu.pl

* Corresponding author. Tel.: +48-12-252-6375; fax: +42-12-252-6902

Received 25 June 2002; accepted 25 June 2002

The first 10% of the full text of this article appears below.

In a recent interesting paper Babaei and Stewart [1] demonstrated that coculture of endothelial cells (ECs) with smooth muscle cells (SMCs) may result in the formation of extensive capillary-like structure. However, the effect was observed only when SMCs were previously transfected with vector containing the endothelial nitric oxide synthase (eNOS) cDNA. Such an in vitro angiogenic-like events were abrogated by L-NAME, a NOS inhibitor. A similar . . . [Full Text of this Article]


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