© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
Dynamics of microvascular oxygen partial pressure in contracting skeletal muscle of rats with chronic heart failure
Departments of Kinesiology, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
* Corresponding author. Tel.: +1-785-532-4523; fax: +1-785-532-4557 musch{at}vet.ksu.edu
Objective: This investigation tested the hypothesis that the dynamics of muscle microvascular O2 pressure (PO2m, which reflects the ratio of O2 utilization [
O2] to O2 delivery [
O2]) following the onset of contractions would be altered in chronic heart failure (CHF). Methods: Female Sprague–Dawley rats were subjected to a myocardial infarction (MI) or a sham operation (Sham). Six to 10 weeks post Sham (n = 6) or MI (n = 17), phosphorescence quenching techniques were utilized to determine PO2m dynamics at the onset of spinotrapezius muscle contractions (1 Hz). Results: MI rats were separated into groups with Moderate (n = 10) and Severe (n = 7) CHF based upon the degree of left ventricular (LV) dysfunction as indicated by structural abnormalities (increased right ventricle weight and lung weight normalized to body weight). LV end-diastolic pressure was elevated significantly in both CHF groups compared with Sham (Sham, 3±1; Moderate CHF, 9±2; Severe CHF, 27±4 mmHg, P<0.05). The PO2m response was modeled using time delay and exponential components to fit the PO2m response to the steady-state. Compared with Shams, the time constant (
) of the primary PO2m response was significantly speeded in Moderate CHF (, Sham, 19.0±1.5; Moderate CHF, 13.2±1.9 s, P<0.05) and slowed in Severe CHF (, 28.2±3.4 s, P<0.05). Within the Severe CHF group, increased linearly with the product of right ventricular and lung weight (r = 0.83, P<0.05). Conclusions: These results suggest that CHF alters the dynamic matching of muscle O2-to-O2 across the transition from rest to contractions and that the nature of that perturbation is dependent upon the severity of cardiac dysfunction.
KEYWORDS Heart failure; Infarction; Oxygen consumption
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. A. Sperandio, A. Borghi-Silva, A. Barroco, L. E. Nery, D. R. Almeida, and J. A. Neder Microvascular oxygen delivery-to-utilization mismatch at the onset of heavy-intensity exercise in optimally treated patients with CHF Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1720 - H1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Copp, L. F. Ferreira, K. F. Herspring, D. M. Hirai, B. S. Snyder, D. C. Poole, and T. I. Musch The effects of antioxidants on microvascular oxygenation and blood flow in skeletal muscle of young rats Exp Physiol, September 1, 2009; 94(9): 961 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Herspring, L. F. Ferreira, S. W. Copp, B. S. Snyder, D. C. Poole, and T. I. Musch Effects of antioxidants on contracting spinotrapezius muscle microvascular oxygenation and blood flow in aged rats J Appl Physiol, December 1, 2008; 105(6): 1889 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Harper, L. F. Ferreira, B. J. Lutjemeier, D. K. Townsend, and T. J. Barstow Matching of blood flow to metabolic rate during recovery from moderate exercise in humans Exp Physiol, October 1, 2008; 93(10): 1118 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Ferreira, S. Koga, and T. J. Barstow Dynamics of noninvasively estimated microvascular O2 extraction during ramp exercise J Appl Physiol, December 1, 2007; 103(6): 1999 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Behnke, M. D. Delp, D. C. Poole, and T. I. Musch Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation J Appl Physiol, November 1, 2007; 103(5): 1757 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Bauer, J. E.B. Reusch, M. Levi, and J. G. Regensteiner Skeletal Muscle Deoxygenation After the Onset of Moderate Exercise Suggests Slowed Microvascular Blood Flow Kinetics in Type 2 Diabetes Diabetes Care, November 1, 2007; 30(11): 2880 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Poole and L. F. Ferreira Muscle-energetic and cardio-pulmonary determinants of exercise tolerance in humans: Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling Exp Physiol, March 1, 2007; 92(2): 341 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lawler, H.-B. Kwak, W. Song, and J. L. Parker Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1756 - R1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Harper, L. F. Ferreira, B. J. Lutjemeier, D. K. Townsend, and T. J. Barstow Human femoral artery and estimated muscle capillary blood flow kinetics following the onset of exercise Exp Physiol, July 1, 2006; 91(4): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Behnke, D. J. Padilla, L. F. Ferreira, M. D. Delp, T. I. Musch, and D. C. Poole Effects of arterial hypotension on microvascular oxygen exchange in contracting skeletal muscle J Appl Physiol, March 1, 2006; 100(3): 1019 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. MacPhee, J. K. Shoemaker, D. H. Paterson, and J. M. Kowalchuk Kinetics of O2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain J Appl Physiol, November 1, 2005; 99(5): 1822 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kano, D. J. Padilla, B. J. Behnke, K. S. Hageman, T. I. Musch, and D. C. Poole Effects of eccentric exercise on microcirculation and microvascular oxygen pressures in rat spinotrapezius muscle J Appl Physiol, October 1, 2005; 99(4): 1516 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. McDonough, B. J Behnke, D. J Padilla, T. I Musch, and D. C Poole Control of microvascular oxygen pressures in rat muscles comprised of different fibre types J. Physiol., March 15, 2005; 563(3): 903 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Finsen, G. Christensen, and I. Sjaastad Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse J Appl Physiol, February 1, 2005; 98(2): 680 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole Effects of chronic heart failure in rats on the recovery of microvascular PO2 after contractions in muscles of opposing fibre type Exp Physiol, July 1, 2004; 89(4): 473 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Datta, T. Tufnell-Barrett, R. A. Bleasdale, C. J.H. Jones, I. Beeton, V. Paul, M. Frenneaux, and P. James Red Blood Cell Nitric Oxide as an Endocrine Vasoregulator: A Potential Role in Congestive Heart Failure Circulation, March 23, 2004; 109(11): 1339 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole Recovery of microvascular PO2 during the exercise off-transient in muscles of different fiber type J Appl Physiol, March 1, 2004; 96(3): 1039 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.J Behnke, M.D Delp, P McDonough, S.A Spier, D.C Poole, and T.I Musch Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type Cardiovasc Res, February 1, 2004; 61(2): 325 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Richardson, C. A. Kindig, T. I. Musch, and D. C. Poole Effects of chronic heart failure on skeletal muscle capillary hemodynamics at rest and during contractions J Appl Physiol, September 1, 2003; 95(3): 1055 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J Behnke, P. McDonough, D. J Padilla, T. I Musch, and D. C Poole Oxygen exchange profile in rat muscles of contrasting fibre types J. Physiol., June 1, 2003; 549(2): 597 - 605. [Abstract] [Full Text] [PDF]
|
|