Skip Navigation

Cardiovascular Research 2002 56(2):260-268; doi:10.1016/S0008-6363(02)00540-0
© 2002 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by De Sousa, E.
Right arrow Articles by Ventura-Clapier, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Sousa, E.
Right arrow Articles by Ventura-Clapier, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2002, European Society of Cardiology

Cardiac and skeletal muscle energy metabolism in heart failure: beneficial effects of voluntary activity

Elvira De Sousaa, Patrick Lechênea, Dominique Fortina, Benoît N’Guessanb, Souad Belmadania, Xavier Bigardb, Vladimir Vekslera and Renée Ventura-Clapiera,*

aU-446 INS.E.RM, Université Paris-Sud, 5 rue Jean-Baptiste Clément 92296 Châtenay-Malabry, France
bCRSSA, 38702 La-Tronche, Cedex, France

renee.ventura{at}cep.u-psud.fr

* Corresponding author. Tel.: +33-1-4683-5762; fax: +33-1-4683-5475.

Objective: Mitochondrial function and metabolic profile of slow and fast skeletal muscles and cardiac muscle are altered in chronic heart failure (CHF), suggesting a generalized metabolic myopathy in this disease. The aim of this study was to investigate the potential beneficial effects of voluntary activity on cardiac and skeletal muscle energetics in heart failure. Methods: Heart failure was induced in rats by aortic stenosis. Four months after surgery, part of sham and CHF animals were randomly assigned to activity cages equipped with running wheels for 8 weeks or kept sedentary. Mitochondrial capacity and regulation were measured using saponin skinned fibers in left ventricle, slow and fast skeletal muscles, and metabolic and myosin profiles were established. Results: Despite four times lower performances of CHF rats, alterations in metabolic and myosin parameters (oxidative capacity, mitochondrial enzymes, cytosolic and mitochondrial creatine kinase, myosin heavy chains) observed in all muscles of CHF animals were almost fully restored in soleus muscle though unchanged in heart and fast skeletal muscles. Conclusions: These results show the powerful beneficial effect of physical activity specifically on active slow oxidative skeletal muscle in CHF, without the worsening of cardiac muscle metabolism.

KEYWORDS Energy metabolism; Glycolysis; Heart failure; Mitochondria; Oxidative phosphorylation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
O. J. Kemi, M. A. Hoydal, P. M. Haram, A. Garnier, D. Fortin, R. Ventura-Clapier, and O. Ellingsen
Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan
Cardiovasc Res, October 1, 2007; 76(1): 91 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Ventura-Clapier, B. Mettauer, and X. Bigard
Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure
Cardiovasc Res, January 1, 2007; 73(1): 10 - 18.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Zoll, L. Monassier, A. Garnier, B. N'Guessan, B. Mettauer, V. Veksler, F. Piquard, R. Ventura-Clapier, and B. Geny
ACE inhibition prevents myocardial infarction-induced skeletal muscle mitochondrial dysfunction
J Appl Physiol, August 1, 2006; 101(2): 385 - 391.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. Momken, P. Lechene, N. Koulmann, D. Fortin, P. Mateo, B. T. Doan, J. Hoerter, X. Bigard, V. Veksler, and R. Ventura-Clapier
Impaired voluntary running capacity of creatine kinase-deficient mice
J. Physiol., June 15, 2005; 565(3): 951 - 964.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Momken, P. Lechene, R. Ventura-Clapier, and V. Veksler
Voluntary physical activity alterations in endothelial nitric oxide synthase knockout mice
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H914 - H920.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.