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Cardiovascular Research 2002 56(2):181-183; doi:10.1016/S0008-6363(02)00653-3
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Conditional AC type VI expression in the heart: relevant insights into function of inducible target gene expression

Patrick Most, Andrew Remppis and Hugo A Katus*

Department of Medicine, Division of Cardiology, Angiology and Pneumology, University of Heidelberg, 69115 Heidelberg, Germany

* Corresponding author. Tel.: +49-622-156-8670; fax: +49-622-156-5516. hugo_katus@med.uni-heidelberg.de

Received 28 August 2002; accepted 28 August 2002

The first 10% of the full text of this article appears below.

See article by Gao et al. [1] (pages 197–204) in this issue.

Manipulation of the mouse genome by transgenic approaches is a powerful tool to examine gene function as well as interaction of gene products in the intact animal [2–4]. In the past, gain-in-function models were the most frequently used transgenic animals to define the physiological relevance of gene products. In these animals, transgene expression is controlled by well characterized promoter elements that drive transgene expression by their cardio-specificity, while the onset of transgene expression depends on the temporal activation of the promotor employed [5–11]. However, the temporal regulation of transgene expression might prevent investigation of a number of important questions. In . . . [Full Text of this Article]


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