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Cardiovascular Research 2002 55(3):495-505; doi:10.1016/S0008-6363(02)00337-1
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

The importance of manganese superoxide dismutase in delayed preconditioning

Involvement of reactive oxygen species and cytokines

Shiro Hoshidaa,b,*, Nobushige Yamashitaa, Kinya Otsua and Masatsugu Horia

aDepartment of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 591-8025, Japan
bDivision of Cardiology, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Sakai, Japan

hoshidas{at}orh.go.jp

* Corresponding author. Tel.: +81-72-252-3561; fax: +81-72-250-5492

It is clinically important to elucidate the mechanism underlying the delayed preconditioning against ischemia–reperfusion injury observed 24–72 h after sublethal stress such as brief ischemia, hyperthermia and exercise. The time course of induction of myocardial manganese-superoxide dismutase (Mn-SOD) and appearance of the ischemic tolerance coincide well, and the percent increase in Mn-SOD activity and percent reduction of infarct size are correlated well under various stresses. Furthermore, treatments with antisense oligodeoxynucleotides to Mn-SOD completely abolished the delayed preconditioning and any increase in Mn-SOD content. These results indicate that Mn-SOD induction plays a pivotal role in the late phase preconditioning afforded with brief ischemia, hyperthermia and exercise. We also showed that cytokines, e.g., tumor necrosis factor-{alpha} and interleukin-1β, and reactive oxygen species are involved in the process of signal transduction for the Mn-SOD induction.

KEYWORDS Cytokines; Ischemia; Preconditioning


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