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Cardiovascular Research 2002 55(2):239-249; doi:10.1016/S0008-6363(02)00328-0
© 2002 by European Society of Cardiology
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Copyright © 2002, European Society of Cardiology

Extracellular superoxide dismutase and cardiovascular disease

Tohru Fukaia,*, Rodney J Folzb, Ulf Landmessera and David G Harrisona

aDepartment of Medicine, Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322, USA
bDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA

* Corresponding author. Tel.: +1-404-727-8176; fax: +1-404-727-3330 tfukai{at}emory.edu

Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•–), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•– are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

KEYWORDS Atherosclerosis; Endothelial function; Free radicals; Hypertension; Ischemia; Nitric oxide; Reperfusion


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