Skip Navigation

Cardiovascular Research 2002 55(1):1-8; doi:10.1016/S0008-6363(02)00407-8
© 2002 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fozzard, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fozzard, H. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2002, European Society of Cardiology

Cardiac sodium and calcium channels: a history of excitatory currents

Harry A. Fozzard*

Cardiac Electrophysiology Laboratories, The University of Chicago Hospitals, 5841 S. Maryland Avenue, Chicago, IL 60637, USA

* Tel.: +1-773-702-1482; fax: +1-773-702-6789 foz{at}hearts.bsd.uchicago.edu

The entire concept of ion channels as molecular machines to gate ion traffic across the membrane has only recently been generally recognized, even though ion channels are found in almost all cells. Na+ and Ca2+ channels are the basis of excitability, and in the heart they generate the rhythm, coordinating and controling cardiac contraction. Dysfunction of ion channels results in arrhythmias that underlie 20–25% of deaths in the developed world, and some arrhythmias result directly from gene defects in ion channels. This is my personal perspective on the critical ideas and the pioneers in the field of cardiac Na+ and Ca2+ channels.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
H. Abriel
Roles and regulation of the cardiac sodium channel Nav1.5: Recent insights from experimental studies
Cardiovasc Res, December 1, 2007; 76(3): 381 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. M. Nerbonne and R. S. Kass
Molecular Physiology of Cardiac Repolarization
Physiol Rev, October 1, 2005; 85(4): 1205 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. Rosati and D. McKinnon
Regulation of Ion Channel Expression
Circ. Res., April 16, 2004; 94(7): 874 - 883.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. A. Fozzard
Fifty Years of Cardiovascular Science Together
Circ. Res., January 10, 2003; 92(1): 4 - 5.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.