© 2002 by European Society of Cardiology
Copyright © 2002, European Society of Cardiology
Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction
aDepartment of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, OLav Kyrres gt. 3., N-7489 Trondheim, Norway
bInstitute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Oyvind.Ellingsen{at}medisin.ntnu.no
* Corresponding author. Tel.: +47-735-98-822; fax: +47-735-98-613
Objective: Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts. Methods: Adult female Sprague–Dawley rats ran on a treadmill 1.5 h/day, 5 days a week for 8 weeks. Exercise intervals alternated between 8 min at 85–90% of VO2max and 2 min at 50–60%. Training started 4 weeks after ligation of the left coronary artery (TR-INF, n=11) or sham operation (TR-SHAM, n=6). Sedentary animals (SED-SHAM, n=6; SED-INF, n=13) were controls. Results: After 6 weeks VO2max in TR-INF and TR-SHAM leveled off 65% above sedentary controls. In TR-SHAM, left and right ventricle weights were 
25% higher than in SED-SHAM, myocytes were 13% longer; width remained unchanged. At physiological stimulation frequencies, relative myocyte shortening was markedly higher whereas peak systolic [Ca2+] and t1/2 of Ca2+ transient decay were 10–20% lower, indicating higher Ca2+ sensitivity in cardiomyocytes from trained rats, compared to respective controls. In TR-INF the left and right ventricular weights, and myocyte length and width were 15, 23, 12, and 20% less than in SED-INF. Endurance training significantly increased the myocardial SR Ca2+ pump (SERCA-2) and sarcolemmal Na+–Ca2+-exchanger (NCX) protein levels to the extent that TR-INF did not differ from SED-SHAM. Conclusion: This is the first study to show that aerobic endurance training attenuates the ventricular and cellular hypertrophy in failing hearts. Furthermore, training consistently restores contractile function, intracellular Ca2+ handling, and Ca2+-sensitivity in cardiomyocytes from rats with myocardial infarction.
KEYWORDS Heart failure; Hypertrophy; Myocytes
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B.ņa Benito and S. Nattel Exercise training as a treatment for heart failure: potential mechanisms and clinical implications J. Physiol., November 1, 2009; 587(21): 5011 - 5013. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bupha-Intr, J. Laosiripisan, and J. Wattanapermpool Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats J Appl Physiol, October 1, 2009; 107(4): 1105 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Stolen, M. A. Hoydal, O. J. Kemi, D. Catalucci, M. Ceci, E. Aasum, T. Larsen, N. Rolim, G. Condorelli, G. L. Smith, et al. Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy Circ. Res., September 11, 2009; 105(6): 527 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. de Waard and D. J. Duncker Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction J Appl Physiol, September 1, 2009; 107(3): 928 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Jiao, Y. Bai, T. Akaike, H. Takeshima, Y. Ishikawa, and S. Minamisawa Sarcalumenin is essential for maintaining cardiac function during endurance exercise training Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H576 - H582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lenk, R. Schur, A. Linke, S. Erbs, Y. Matsumoto, V. Adams, and G. Schuler Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model Eur J Heart Fail, April 1, 2009; 11(4): 342 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Mou, C. Reboul, L. Andre, A. Lacampagne, and O. Cazorla Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure Cardiovasc Res, February 15, 2009; 81(3): 555 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Shephard, C. Foster, A. Lucia, D. R. Bassett, S. M. Marcora, J. Gonzalez-Alonso, S. P. Mortensen, S. S. Cheung, A. D. Flouris, O. J. Kemi, et al. No support for central governor. J Appl Physiol, January 1, 2009; 106(1): 343 - 344. [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, W. Wan, L. Ji, S. Lao, A. S. Powers, W. Zhao, J. M. Erikson, and J. Q. Zhang Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats Cardiovasc Res, June 1, 2008; 78(3): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Leosco, G. Rengo, G. Iaccarino, L. Golino, M. Marchese, F. Fortunato, C. Zincarelli, E. Sanzari, M. Ciccarelli, G. Galasso, et al. Exercise promotes angiogenesis and improves {beta}-adrenergic receptor signalling in the post-ischaemic failing rat heart Cardiovasc Res, May 1, 2008; 78(2): 385 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Nilsson, B. Hellesnes, A. Westheim, and M. A. Risberg Group-based Aerobic Interval Training in Patients With Chronic Heart Failure: Norwegian Ullevaal Model Physical Therapy, April 1, 2008; 88(4): 523 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chicco, S. A. McCune, C. A. Emter, G. C. Sparagna, M. L. Rees, D. A. Bolden, K. D. Marshall, R. C. Murphy, and R. L. Moore Low-Intensity Exercise Training Delays Heart Failure and Improves Survival in Female Hypertensive Heart Failure Rats Hypertension, April 1, 2008; 51(4): 1096 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, M. A. Hoydal, P. M. Haram, A. Garnier, D. Fortin, R. Ventura-Clapier, and O. Ellingsen Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan Cardiovasc Res, October 1, 2007; 76(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ventura-Clapier, B. Mettauer, and X. Bigard Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure Cardiovasc Res, January 1, 2007; 73(1): 10 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Adams, A. Linke, U. Wisloff, C. Doring, S. Erbs, N. Krankel, C. C. Witt, S. Labeit, U. Muller-Werdan, G. Schuler, et al. Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility Cardiovasc Res, January 1, 2007; 73(1): 120 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, P. M. Haram, J. P. Loennechen, J.-B. Osnes, T. Skomedal, U. Wisloff, and O. Ellingsen Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function Cardiovasc Res, July 1, 2005; 67(1): 161 - 172. [Abstract] [Full Text] [PDF]
|
|