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Cardiovascular Research 2002 53(2):290-291; doi:10.1016/S0008-6363(01)00561-2
© 2002 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Removal of intracellular Mg2+ activates cardiac Na+/Ca2+ exchanger

Tatsuto Kiyosue*

Department of Physiology, Oita Medical University, 1-1 Idai-ga-oka, Hasama, Oita 879-5593, Japan

kiyosue@oita-med.ac.jp

* Tel.: +81-975-865-651; fax: +81-975-496-046

Received 4 December 2001; accepted 4 December 2001

The first 10% of the full text of this article appears below.

See article by Wei et al. [1] (pages 334–340) in this issue.


   1. Effects of intracellular Mg2+ and ATP on NCX
 
The Na+/Ca2+ exchanger (NCX) expels Ca2+ from myocytes in exchange for extracellular Na+ and balances Ca2+ influx through L-type Ca2+ channels during cardiac excitation. In this issue of Cardiovascular Research, Wei et al. [1] report that cardiac NCX is regulated by intracellular Mg2+ (Mg2+i). Their results suggest some similarities of mammalian cardiac NCX to that of squid nerves (NCX-SQ) [2]. In squid nerve, rapid removal of Mg2+i produced marked activation of the exchanger. Further removal of ATP did not suppress the activated NCX-SQ, but readmission of Mg2+i abolished this NCX-SQ stimulation. Phosphatidylinositols, which are . . . [Full Text of this Article]


   2. Similarities to the regulation of cardiac L-type Ca2+ channel by Mg2+i
 

   3. Mg2+i under normal and pathophysiological conditions
 

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