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Cardiovascular Research 2001 52(3):519-520; doi:10.1016/S0008-6363(01)00481-3
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

Transient outward K+ current, ito, in the sinoatrial node

M.R Boyetta,*, H Honjob, M Leic and I Kodamab

aDepartment of Physiology, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
bResearch Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan
cUniversity Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK

* Corresponding author. Tel.: +44-113-233-4298; fax: +44-113-233-4224 m.r.boyett@leeds.ac.uk

Received 17 September 2001; accepted 17 September 2001

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The transient outward K+ current, ito, is a major current in the heart. It is responsible for the early phase of repolarization (phase 1) in some regions of the heart and it can control action potential duration, e.g. Refs. [1,2]. We and others have argued that it contributes to the regional differences in electrical activity in different regions of the heart, such as across the ventricular wall [3] and in the sinoatrial (SA) node [4]. It also contributes to electrical remodelling, e.g. Ref. [5].

We have measured ito in rabbit SA node cells [6,7]. In their letter, A.O. Verkerk and A.C.G. van Ginneken point out that the recordings of ito during . . . [Full Text of this Article]


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S. P. Patel and D. L. Campbell
Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms
J. Physiol., November 15, 2005; 569(1): 7 - 39.
[Abstract] [Full Text] [PDF]