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Cardiovascular Research 2001 52(2):178-180; doi:10.1016/S0008-6363(01)00456-4
© 2001 by European Society of Cardiology
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Copyright © 2001, European Society of Cardiology

A transcriptional regulator of osteogenesis expressed in calcifying atherosclerotic plaques

Nicholas P.J Brindle*

University of Leicester, Department of Surgery, RKCSB, P.O. Box 65, Leicester LE2 7LX, UK

npjb1@leicester.ac.uk

* Tel.: +44-116-252-5802; fax: +44-116-252-3179

Received 24 August 2001; accepted 30 August 2001

The first 10% of the full text of this article appears below.

See article by Engelse et al. [9] (pages 281–289) in this issue.

Calcification is a common feature of atherosclerotic plaques. Even early lesions of young adults have been found to contain small aggregates of crystalline calcium within the lipid core [1]. As plaque size and complexity increase the amount of calcium within the lesion grows [1]. The degree of plaque calcification correlates with increased risk of coronary disease-related events [2], though the precise ways in which calcification influences plaque pathology remain to be resolved. Coronary vessels with extensively calcified plaques are more prone to dissections during angioplasty and carry a higher risk of operative complications [3]. Deposition of calcium within vessels also occurs in the . . . [Full Text of this Article]


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