© 2001 by European Society of Cardiology
Copyright © 2001, European Society of Cardiology
Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease
aMax Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
bDepartment of Cardiology and Cardiovascular Pathology, University of Amsterdam, Academic Medical Center, Room B2-250, Meibergdreef 9, 1105 Amsterdam, The Netherlands
* Corresponding author. Tel.: +31-20-566-2749; fax: +31-20-696-2609 vanroyen{at}med1.ukl.uni-freiburg.de
After birth two forms of vessel growth can be observed; angiogenesis and arteriogenesis. Angiogenesis refers to the formation of capillary networks. Arteriogenesis refers to the growth of preexistent collateral arterioles leading to formation of large conductance arteries that are well capable to compensate for the loss of function of occluded arteries. The process of arteriogenesis is initiated when shear stresses increase in the preexistent collateral pathways upon narrowing of a main artery. The increased shear stress leads to an upregulation of cell adhesion molecules for circulating monocytes, which accumulate subsequently around the proliferating arteries and provide the several required cytokines and growth factors. Several strategies are currently tested for their potential to stimulate the process of arteriogenesis. These strategies focus either at shear stress, at direct stimulation of endothelial and smooth muscle cell growth or at the monocytic pathway and promising results were obtained from experimental studies. However, some important questions remain to be answered before arteriogenesis can be brought from bench to bedside.
KEYWORDS HIF-1, hypoxia inducible factor-1; NOS, nitric oxide synthetase; VEGF, vascular endothelial growth factor; FGF-1, fibroblast growth factor 1; MCP-1, monocyte chemoattractant protein-1; TNF-
, tumor necrosis factor-; b-FGF, basic fibroblast growth Factor; MMP, matrix metalloproteinase; GM-CSF, granulocyte-monocyte colony-stimulating factor; ICAM, intercellular adhesion molecule; TGF-β, transforming growth factor-β; IL-1, interleukin 1; PDGF, platelet derived growth factor; TGF-, transforming growth factor-; PIGF, placenta growth factor
1 Dr. J.J. Piek is clinical investigator for the Netherlands Heart Foundation (grant No. D96.020).
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Zimpfer, S. Aharinejad, J. Holfeld, A. Thomas, J. Dumfarth, R. Rosenhek, M. Czerny, W. Schaden, M. Gmeiner, E. Wolner, et al. Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 963 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zacharek, J. Chen, X. Cui, Y. Yang, and M. Chopp Simvastatin Increases Notch Signaling Activity and Promotes Arteriogenesis After Stroke Stroke, January 1, 2009; 40(1): 254 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Keeley, B. Mehrad, and R. M. Strieter Chemokines as Mediators of Neovascularization Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1928 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takaba, C. Jiang, S. Nemoto, Y. Saji, T. Ikeda, S. Urayama, T. Azuma, A. Hokugo, S. Tsutsumi, Y. Tabata, et al. A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: Evolving concept of biologic coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 891 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. van Royen, S. H. Schirmer, B. Atasever, C. Y.H. Behrens, D. Ubbink, E. E. Buschmann, M. Voskuil, P. Bot, I. Hoefer, R. O. Schlingemann, et al. START Trial: A Pilot Study on STimulation of ARTeriogenesis Using Subcutaneous Application of Granulocyte-Macrophage Colony-Stimulating Factor as a New Treatment for Peripheral Vascular Disease Circulation, August 16, 2005; 112(7): 1040 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kojda and R. Hambrecht Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Cardiovasc Res, August 1, 2005; 67(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sandri, V. Adams, S. Gielen, A. Linke, K. Lenk, N. Krankel, D. Lenz, S. Erbs, D. Scheinert, F. W. Mohr, et al. Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor Cells in Patients With Ischemic Syndromes: Results of 3 Randomized Studies Circulation, June 28, 2005; 111(25): 3391 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Loirand, M. Rolli-Derkinderen, and P. Pacaud RhoA and resistance artery remodeling Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1051 - H1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, B. M. Prior, H. Li, H. T. Yang, and R. L. Terjung VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise-trained rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H759 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hosaka, H. Koyama, T. Kushibiki, Y. Tabata, N. Nishiyama, T. Miyata, H. Shigematsu, T. Takato, and H. Nagawa Gelatin Hydrogel Microspheres Enable Pinpoint Delivery of Basic Fibroblast Growth Factor for the Development of Functional Collateral Vessels Circulation, November 23, 2004; 110(21): 3322 - 3328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Schirmer, I. R. Buschmann, M. M. Jost, I. E. Hoefer, S. Grundmann, J.-P. Andert, S. Ulusans, C. Bode, J. J. Piek, and N. van Royen Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis Cardiovasc Res, November 1, 2004; 64(2): 356 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Prior, H. T. Yang, and R. L. Terjung What makes vessels grow with exercise training? J Appl Physiol, September 1, 2004; 97(3): 1119 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. E. Hoefer, N. van Royen, J. E. Rectenwald, E. Deindl, J. Hua, M. Jost, S. Grundmann, M. Voskuil, C. K. Ozaki, J. J. Piek, et al. Arteriogenesis Proceeds via ICAM-1/Mac-1- Mediated Mechanisms Circ. Res., May 14, 2004; 94(9): 1179 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. van Royen, M. Voskuil, I. Hoefer, M. Jost, S. de Graaf, F. Hedwig, J.-P. Andert, T.A.M. Wormhoudt, J. Hua, S. Hartmann, et al. CD44 Regulates Arteriogenesis in Mice and Is Differentially Expressed in Patients With Poor and Good Collateralization Circulation, April 6, 2004; 109(13): 1647 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Porat, M. Grunewald, A. Globerman, A. Itin, G. Barshtein, L. Alhonen, K. Alitalo, and E. Keshet Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies Circ. Res., February 20, 2004; 94(3): 394 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kondoh, H. Koyama, T. Miyata, T. Takato, H. Hamada, and H. Shigematsu Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor Cardiovasc Res, January 1, 2004; 61(1): 132 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C Hershey, H. A Corcoran, E. P Baskin, D. B Gilberto, X. Mao, K. A Thomas, and J. J Cook Enhanced hindlimb collateralization induced by acidic fibroblast growth factor is dependent upon femoral artery extraction Cardiovasc Res, October 1, 2003; 59(4): 997 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hao, G. Gabbiani, and M.-L. Bochaton-Piallat Arterial Smooth Muscle Cell Heterogeneity: Implications for Atherosclerosis and Restenosis Development Arterioscler Thromb Vasc Biol, September 1, 2003; 23(9): 1510 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R Strauch Building better blood vessels: new insight on the molecular control of arteriogenesis Cardiovasc Res, September 1, 2003; 59(3): 532 - 533. [Full Text] [PDF]
|
|
|
|
 |
|
 N. van Royen, J. J Piek, D. A Legemate, W. Schaper, J. Oskam, B. Atasever, M. Voskuil, D. Ubbink, S. H Schirmer, I. Buschmann, et al. Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial Vascular Medicine, August 1, 2003; 8(3): 191 - 196. [Abstract] [PDF]
|
|
|
|
|
|
W. Schaper and D. Scholz Factors Regulating Arteriogenesis Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1143 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. O. Bonetti, D. R. Holmes Jr, A. Lerman, and G. W. Barsness Enhanced external counterpulsation for ischemic heart disease: What's behind the curtain? J. Am. Coll. Cardiol., June 4, 2003; 41(11): 1918 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Koerselman, Y. van der Graaf, P. P.Th. de Jaegere, and D. E. Grobbee Coronary Collaterals: An Important and Underexposed Aspect of Coronary Artery Disease Circulation, May 20, 2003; 107(19): 2507 - 2511. [Full Text] [PDF]
|
|
|
|
|
|
A. Luttun and P. Carmeliet De novo vasculogenesis in the heart Cardiovasc Res, May 1, 2003; 58(2): 378 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roguin, A. Avivi, S. Nitecki, I. Rubinstein, N. S. Levy, Z. A. Abassi, M. B. Resnick, O. Lache, M. Melamed-Frank, A. Joel, et al. Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF PNAS, April 15, 2003; 100(8): 4644 - 4648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Voskuil, N. van Royen, I. E. Hoefer, R. Seidler, B. D. Guth, C. Bode, W. Schaper, J. J. Piek, and I. R. Buschmann Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1 Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1422 - H1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Deindl, I. E. Hoefer, B. Fernandez, M. Barancik, M. Heil, M. Strniskova, and W. Schaper Involvement of the Fibroblast Growth Factor System in Adaptive and Chemokine-Induced Arteriogenesis Circ. Res., March 21, 2003; 92(5): 561 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Buckwalter, V. C. Curtis, Z. Valic, S. B. Ruble, and P. S. Clifford Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide J Appl Physiol, March 1, 2003; 94(3): 935 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. van Royen, I. Hoefer, M. Bottinger, J. Hua, S. Grundmann, M. Voskuil, C. Bode, W. Schaper, I. Buschmann, and J.J. Piek Local Monocyte Chemoattractant Protein-1 Therapy Increases Collateral Artery Formation in Apolipoprotein E-Deficient Mice but Induces Systemic Monocytic CD11b Expression, Neointimal Formation, and Plaque Progression Circ. Res., February 7, 2003; 92(2): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N van Royen, I Hoefer, I Buschmann, S Kostin, M Voskuil, C. Bode, W Schaper, and J.J Piek Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits Cardiovasc Res, January 1, 2003; 57(1): 178 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, H. T. Yang, and R. L. Terjung Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2528 - H2538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Tuttle, R. D. Nachreiner, A. S. Bhuller, K. W. Condict, B. A. Connors, B. P. Herring, M. C. Dalsing, and J. L. Unthank Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1380 - H1389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yokoyama and T. Hirase Harmonic Interplay of Angiogenic Growth Factors in the Development of Coronary Blood Vessels Circ. Res., June 8, 2001; 88(11): 1099 - 1101. [Full Text] [PDF]
|
|