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Cardiovascular Research 2000 48(3):365-366; doi:10.1016/S0008-6363(00)00239-X
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Chloride ions and the endothelium: their role in adrenoceptor-mediated vasoconstriction

M.Yvonne Alexander*

Department of Medicine and Therapeutics, University of Glasgow, Glasgow, G11 6NT, UK

* Tel.: +44-141-211-2111; fax: +44-141-211-1763 yalexander@clinmed.gla.ac.uk

Received 13 September 2000; accepted 27 September 2000

The first 10% of the full text of this article appears below.

See article by Tabrizchi and Duggan [1] (pages 393–401) in this issue.

This report by Tabrizchi and Duggan [1] represents another link in the continuing effort to evaluate factors involved in the regulation of vascular tone. Much of the early work in this regard focussed on the findings by Furchgott and Zawadski [2] that endothelial derived relaxing factor (EDRF) is responsible for acetylcholine-induced vasodilation and the later independent reports of Ignarro and Moncada identifying EDRF as nitric oxide (NO) [3–4]. This led to a huge wealth of information drawn from in vitro and in vivo studies correlating . . . [Full Text of this Article]


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