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Cardiovascular Research 2000 48(1):8-10; doi:10.1016/S0008-6363(00)00189-9
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Cardiac gap junctions: good or bad?

G. Taimor*

Physiologisches Institut, Justus-Liebig-Universität, Aulweg 129, 35392 Gießen, Germany

* Tel.: +49-641-994-7246; fax: +49-641-994-7239 gerhild.taimor@physiologie.med.uni-giessen.de

Received 27 July 2000; accepted 31 July 2000

KEYWORDS Apoptosis; Cardiomyocytes; Gap junctions; Ischemia; Reperfusion

The first 10% of the full text of this article appears below.

See article by Yasui et al. [30] (pp. 68–76) in this issue.

Gap junctions enable the cytoplasm of individual cells to communicate directly and allow exchange of nutrients, ions, metabolites and small molecules up to about 1000 Da [1]. Connexins, which are coded for by a multigene family, are the subunits of gap junctions. In adult mammalian myocardium four different connexins, connexin43 (Cx43), Cx40, Cx45 and Cx37, have been identified [2]. In heterozygous Cx43+/– mice connexin43 has been shown to be the main conductor of intercellular current in the ventricle [3]. The gap junctions are mainly localized at the intercalated discs of the cardiomyocytes [4].

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