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Cardiovascular Research 2000 47(2):404-405; doi:10.1016/S0008-6363(00)00125-5
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Nitrovasodilators and heart rate: more than the arterial baroreflex

P. Musialek* and B. Casadei

Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK

* Corresponding author. Tel.: +44-1865-220428; fax: +44-1865-768844 piotr.musialek@clinical-medicine.ox.ac.uk

Received 5 May 2000; accepted 11 May 2000

The first 10% of the full text of this article appears below.

We read with interest a recent study by Mésangeau et al. [1], which evaluates the development of cardiovascular autonomic neuropathy in a pig model of streptozotocin-induced diabetes.

In addition to spectral analysis of short-term arterial blood pressure (ABP) and heart rate (HR) variability, this investigation involved determination of the baroreceptor-HR reflex with vasoactive drugs. The sensitivity of the baroreceptor-HR reflex was calculated by plotting the HR response to changes in ABP obtained by a . . . [Full Text of this Article]


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