Skip Navigation

Cardiovascular Research 2000 47(2):234-243; doi:10.1016/S0008-6363(00)00113-9
© 2000 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pedersen, H. D.
Right arrow Articles by Häggström, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pedersen, H. D.
Right arrow Articles by Häggström, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2000, European Society of Cardiology

Mitral valve prolapse in the dog: a model of mitral valve prolapse in man

Henrik D. Pedersena,* and Jens Häggströmb

aDepartment of Anatomy and Physiology, Royal Veterinary and Agricultural University, Grønnegårdsvej 7, DK-1870 Frederiksberg C, Denmark
bDepartment of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden

* Corresponding author. Tel.: +45-35-282-526; fax: +45-35-282-525 hdp@kvl.dk

Received 21 January 2000; accepted 25 April 2000

KEYWORDS Aging; Epidemiology; Renin angiotensin system; Ultrasound; Valve (disease)

The first 150 words of the full text of this article appear below.


   1 Introduction
 
Mitral valve prolapse (MVP), i.e. abnormal systolic protrusion of mitral valve leaflets into the left atrium, is a common cause of severe mitral regurgitation (MR) requiring operation in people living in industrialized nations [1,2]. MVP has been reported to have many causes but in the majority of cases it is a primary condition (called primary MVP in this paper) characterized by a progressive myxomatous degeneration of the mitral valve leaflets and chordae tendineae [1–3]. The disease typically emerges in adolescence but complications such as severe MR usually do not occur until middleage or senescence [1–3]. An animal model with a shorter course of disease could be useful in several ways, for instance, by making it feasible to evaluate the effects of different drugs on disease progression. Despite this, no animal model of primary MVP has been described so far.

From pathological studies, it has long been known . . . [Full Text of this Article]


   2 Pathology
 

   3 Etiology and pathogenesis
 

   4 Epidemiology and natural history
 

   5 Auscultatory findings
 

   6 Two-dimensional echocardiography
 

   7 Possible associations with other conditions
 
7.1 Changes in the circulating renin–angiotensin system
7.2 Respiratory sinus arrhythmia
7.3 Hypomagnesemia
7.4 Platelet activation

   8 Concluding remarks
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
J. M. Connolly, M. A. Bakay, J. T. Fulmer, R. C. Gorman, J. H. Gorman III, M. A. Oyama, and R. J. Levy
Fenfluramine Disrupts the Mitral Valve Interstitial Cell Response to Serotonin
Am. J. Pathol., September 1, 2009; 175(3): 988 - 997.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
K. B. Donnelly
Cardiac Valvular Pathology: Comparative Pathology and Animal Models of Acquired Cardiac Valvular Diseases
Toxicol Pathol, February 1, 2008; 36(2): 204 - 217.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
C. S. Elangbam, K. A. Colman, R. M. Lightfoot, R. D. Tyler, and H. G. Wall
Endocardial Myxomatous Change in Harlan Sprague-Dawley Rats (Hsd:S--D) and CD-1 Mice: Its Microscopic Resemblance to Drug-Induced Valvulopathy in Humans
Toxicol Pathol, June 1, 2002; 30(4): 483 - 491.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
T.O. Cheng
Comparison of mitral valve prolapse in dogs and humans
Cardiovasc Res, January 1, 2001; 49(1): 244 - 245.
[Full Text] [PDF]