© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Re: Ventricular arrhythmias induced by endothelin-1 or by acute ischemia: a comparative analysis using three dimensional mapping (Cardiovasc Res 2000;45:310–320)
rat Duru*University Hospital of Zurich, Cardiac Arrhythmia Unit, Ramistr. 100, 8091 Zurich, Switzerland
* Corresponding author. Tel.: 41-1-255-1111; fax: +41-1-255-4597 karduf@usz.unizh.ch
Received 22 February 2000; accepted 23 March 2000
KEYWORDS Arrhythmia (mechanisms); Endothelins; Hormones; Mapping; Ventricular arrhythmias
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Dear Editor,
We read with great interest the study by Becker et al. [1] in which they analyzed the three-dimensional activation patterns of ventricular arrhythmias induced by endothelin-1 (ET-1) in comparison with ischemia-induced arrhythmias. In order to support the hypothesis that ET-1 exerts an intrinsic arrhythmogenic effect which is not attributable to ischemia,