© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
1750 Biomedical Science Tower, Cardiovascular Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
* Corresponding author. Tel.: +1-412-648-3016; fax: +1-412-383-8857 liyy{at}msx.upmc.edu
Myocardial fibrosis due to maladaptive extracellular matrix remodeling contributes to dysfunction of the failing heart. Further elucidation of the mechanism by which myocardial fibrosis and dilatation can be prevented or even reversed remains of great interest as a potential means to limit myocardial remodeling and dysfunction. Matrix metalloproteinases (MMPs) are the driving force behind extracellular matrix degradation during remodeling and are increased in the failing human heart. MMPs are regulated by a variety of growth factors, cytokines, and matrix fragments such as matrikines. In the present report, we discuss the regulation of MMPs, the role of MMPs in the development of cardiac fibrosis, and the modulation of MMP activity using gene transfer and knockout technologies. We also present recent findings from our laboratory on the regulation of the extracellular MMP inducer (EMMPRIN), MMPs, and transforming growth factor-β1 in the failing human heart before and after left ventricular assist device support, as well as the possibility of preventing ventricular fibrosis using different anti-MMP strategies. Several studies suggest that such modulation of MMP activity can alter ventricular remodeling, myocardial dysfunction, and the progression of heart failure. It is therefore suggested that the interplay of MMPs and their regulators is important in the development of the heart failure phenotype, and myocardial fibrosis in heart failure may be modified by modulating MMP activity.
KEYWORDS Extracellular matrix; Gene therapy; Remodeling; Heart failure; Fibrosis
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|
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|
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|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Blatt, D. Robinson, G. Cotter, S. Efrati, Y. Simantov, I. Bar, E. Kaluski, R. Krakover, S. Sidenko, Z. Evron, et al. Improved regional left ventricular function after successful satellite cell grafting in rabbits with myocardial infarction Eur J Heart Fail, December 1, 2003; 5(6): 751 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Balasubramanian and D. Kuppuswamy RGD-containing Peptides Activate S6K1 through {beta}3 Integrin in Adult Cardiac Muscle Cells J. Biol. Chem., October 24, 2003; 278(43): 42214 - 42224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B Jones, D. C Sane, and D. M Herrington Matrix metalloproteinases: A review of their structure and role in acute coronary syndrome Cardiovasc Res, October 1, 2003; 59(4): 812 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 T. Betsuyaku, M. Tanino, K. Nagai, Y. Nasuhara, M. Nishimura, and R. M. Senior Extracellular Matrix Metalloproteinase Inducer Is Increased in Smokers' Bronchoalveolar Lavage Fluid Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 222 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herget, J. Novotna, J. Bibova, V. Povysilova, M. Vankova, and V. Hampl Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats Am J Physiol Lung Cell Mol Physiol, July 1, 2003; 285(1): L199 - L208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, S. Oparil, J. A. Feng, P. Li, G. Perry, L. B. Chen, M. Dai, S. W.M. John, and Y.-F. Chen Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide-Null Mouse Hypertension, July 1, 2003; 42(1): 88 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Betsuyaku, K. Kadomatsu, G. L. Griffin, T. Muramatsu, and R. M. Senior Increased Basigin in Bleomycin-Induced Lung Injury Am. J. Respir. Cell Mol. Biol., May 1, 2003; 28(5): 600 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Marin, V. Roldan, V. Climent, A. Garcia, P. Marco, and G. Y.H. Lip Is Thrombogenesis in Atrial Fibrillation Related to Matrix Metalloproteinase-1 and Its Inhibitor, TIMP-1? Stroke, May 1, 2003; 34(5): 1181 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. King, M. L. Coker, A. Goldberg, J. H. McElmurray III, H. R. Gunasinghe, R. Mukherjee, M. R. Zile, T. P. O'Neill, and F. G. Spinale Selective Matrix Metalloproteinase Inhibition With Developing Heart Failure: Effects on Left Ventricular Function and Structure Circ. Res., February 7, 2003; 92(2): 177 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, L. Liu, H. Chen, T. Sawamura, S. Ranganathan, and J. L. Mehta LOX-1 Mediates Oxidized Low-Density Lipoprotein-Induced Expression of Matrix Metalloproteinases in Human Coronary Artery Endothelial Cells Circulation, February 4, 2003; 107(4): 612 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. J. M. Creemers, J. N. Davis, A. M. Parkhurst, P. Leenders, K. B. Dowdy, E. Hapke, A. M. Hauet, P. G. Escobar, J. P. M. Cleutjens, J. F. M. Smits, et al. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H364 - H371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Suzuki, H. Morita, T. Mishima, V. G. Sharov, A. Todor, E. J. Tanhehco, A. E. Rudolph, E. G. McMahon, S. Goldstein, and H. N. Sabbah Effects of Long-Term Monotherapy With Eplerenone, a Novel Aldosterone Blocker, on Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure Circulation, December 3, 2002; 106(23): 2967 - 2972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pauschinger, K. Chandrasekharan, J. Li, W. Poller, M. Noutsias, C. Tschope, and H.-P. Schultheiss Inflammation and extracellular matrix protein metabolism: two sides of myocardial remodelling Eur. Heart J. Suppl., December 1, 2002; 4(suppl_I): I49 - I53. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Stroud, C. F. Baicu, M. A. Barnes, F. G. Spinale, and M. R. Zile Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2324 - H2335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fraccarollo, P. Galuppo, J. Bauersachs, and G. Ertl Collagen accumulation after myocardial infarction: effects of ETA receptor blockade and implications for early remodeling: Presented in part at the 72nd Scientific Session of the American Heart Association, Atlanta, GA, USA, November 7-10, 1999, and published in abstract form (Circulation 1999;100(Suppl. 1):562) Cardiovasc Res, June 1, 2002; 54(3): 559 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. W.-T. Shek, R. C. Benyon, F. M. Walker, P. R. McCrudden, S. L. F. Pender, E. J. Williams, P. A. Johnson, C. D. Johnson, A. C. Bateman, D. R. Fine, et al. Expression of Transforming Growth Factor-{beta}1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis Am. J. Pathol., May 1, 2002; 160(5): 1787 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Fan and M. J. Karnovsky Increased MMP-2 Expression in Connective Tissue Growth Factor Over-expression Vascular Smooth Muscle Cells J. Biol. Chem., March 15, 2002; 277(12): 9800 - 9805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Y. Li, T. Kadokami, P. Wang, C. F. McTiernan, and A. M. Feldman MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H983 - H989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Vaillant, M. G. Chiaramonte, A. W. Cheever, P. D. Soloway, and T. A. Wynn Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases J. Immunol., December 15, 2001; 167(12): 7017 - 7026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Leicht, W. Briest, A. Holzl, and H.-G. Zimmer Serum depletion induces cell loss of rat cardiac fibroblasts and increased expression of extracellular matrix proteins in surviving cells Cardiovasc Res, December 1, 2001; 52(3): 429 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Li, Y. Q. Feng, T. Kadokami, C. F. McTiernan, R. Draviam, S. C. Watkins, and A. M. Feldman Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy PNAS, November 7, 2000; 97(23): 12746 - 12751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Saed, W. Zhang, and M. P. Diamond Effect of Hypoxia on Stimulatory Effect of TGF-{beta}1 on MMP-2 and MMP-9 Activities in Mouse Fibroblasts Reproductive Sciences, November 1, 2000; 7(6): 348 - 354. [Abstract] [PDF]
|
|