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Cardiovascular Research 2000 45(3):747-755; doi:10.1016/S0008-6363(99)00275-8
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

The regulation of vascular smooth muscle cell apoptosis

Nicola J. McCarthy and Martin Bennett*

Unit of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, Level 6, Box 110, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK

* Corresponding author. Tel.: +44-1223-762-583; fax: 44-1223-331-505 mrb{at}mole.bio.cam.ac.uk

Apoptosis describes the morphological changes that identify a specific form of regulated cell death. Over recent years, the importance of either aberrant onset or suppression of apoptosis within tissues has become apparent and is associated with the development of several terminal diseases. Here we describe the relevance of apoptosis to the maintenance of vascular homeostasis. Specifically, we address the role of vascular smooth muscle cell death, how this may be regulated at the molecular level and whether any of these molecular mediators will provide targets for intervention in diseases such as atherosclerosis.

KEYWORDS Apoptosis; Smooth muscle; Atherosclerosis; Arteries


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