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Cardiovascular Research 2000 45(2):294-302; doi:10.1016/S0008-6363(99)00358-2
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Angiogenic growth factors

potential new treatment for acute myocardial infarction?

Lino M Gonçalves*

Cardiology Department, Coimbra University Hospital, 3049 Coimbra Codex, Portugal

* Tel.: +351-239-40-0414; fax: +351-239-78-0552 lgoncalv{at}ci.uc.pt

In models of hind-limb ischemia and progressive coronary artery occlusion, angiogenic growth factor proteins and genes expressing growth factors have been shown to induce the development of collateral vessels and remodeling of existing collaterals. The therapeutic potential of growth factors in the setting of acute myocardial infarction may be related to non-angiogenic properties of growth factors as well, and is the focus of this review.

KEYWORDS Collateral circulation; Growth factors; Necrosis


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