© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
Cardiac fatty acid uptake and transport in health and disease
Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
* Corresponding author. Tel.: +31-43-388-1086; fax: +31-43-388-4166 vandervusse{at}fys.unimaas.nl
Fatty acids are important energy donors for the healthy heart. These substrates are supplied to the myocardium bound to albumin to overcome their low solubility in aqueous solutions such as blood plasma. Transport from the microvasular compartment to the mitochondria inside the cardiomyocytes is most likely a combination of passive and protein-mediated diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.
KEYWORDS Cardiomyopathy; Diabetes; Energy metabolism; Heart failure; Hypertrophy
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