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Cardiovascular Research 2000 45(1):68-75; doi:10.1016/S0008-6363(99)00298-9
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Recent advances in cardiac hypertrophy

Giorgio Olivetti*, Elena Cigola, Roberta Maestri, Costanza Lagrasta, Demenico Corradi and Federico Quaini

Department of Pathology, University of Parma, Via Gramsci 41, 43100 Parma, Italy

* Corresponding author. Tel.: +39-0521-29-0386; fax: +39-0521-29-2710 olivetti@ipruniv.cce.unipr.it

KEYWORDS Blood pressure; Hypertension; Hypertrophy; Renal function

The first 150 words of the full text of this article appear below.


   1 Introduction
 
In 1977 Sen, Tarazi and Bumpus in a brief article in Cardiovascular Research discussed the variable effects obtained with anti-hypertensive therapy on cardiac hypertrophy and its regression [1]. Having the aim of intervening with medical treatment on cardiac hypertrophy the authors attained results quite different from the expected one. Although this event is very common in research the authors were able to take advantage from the discrepancy suggesting new hypotheses, possible explanations and innovating conclusions. They found that in spontaneous hypertensive rats (SHR), an animal model that mimics essential hypertension in humans, the vasodilator {alpha}-methyldopa was able to reduce blood pressure, renin activity and reverse cardiac hypertrophy, whereas minoxidil another vasodilator reduced blood pressure, increased heart weight and renin activity. Finally, beta blockade not affecting blood pressure, reduced cardiac mass and renin activity. These results highlighted the uncertainty in the relation between cardiac hypertrophy, arterial blood pressure levels and . . . [Full Text of this Article]


   2 Definition
 

   3 Cardiac hypertrophy and aging
 

   4 Induced cardiac hypertrophy
 

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