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Cardiovascular Research 1999 44(2):450-451; doi:10.1016/S0008-6363(99)00247-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Endothelin-1 in angiotensin II-dependent hypertension

Answer to the Letter to the Editor

Gian Paolo Rossi* and Achille C Pessina

Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy

* Corresponding author. Tel.: +39-(0)49-821-3304 or 2301; fax: +39-49-880-2252 gprossi@ux1.unipd.it

Received 5 August 1999; accepted 5 August 1999

The first 10% of the full text of this article appears below.

We are delighted that our paper [1] succeeded in generating interest and discussion. Gardiner and Bennett raised an important issue concerning the potential role of endothelin-1 (ET-1) in the high blood pressure (BP) of transgenic TGR(mREN-2)27 rats [2], a monogenic renin-dependent model of severe hypertension. As far as we can understand, they found a slow-onset hypotensive effect during an acute 8 hr infusion of a mixed ETA/ETB receptor antagonist (SB 209670) in male heterozygous TGR(mREN-2)27 rats, where they recorded invasively intra-arterial blood pressure [3]. This hypotensive effect was surpassed by that induced by losartan. Interestingly, a synergistic hypotensive effect of . . . [Full Text of this Article]


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P. Rong, D. J. Campbell, and S. L. Skinner
Hypertension in the (mRen-2)27 Rat Is Not Explained by Enhanced Kinetics of Transgenic Ren-2 Renin
Hypertension, October 1, 2003; 42(4): 523 - 527.
[Abstract] [Full Text] [PDF]