Skip Navigation

Cardiovascular Research 1999 44(2):315-324; doi:10.1016/S0008-6363(99)00199-6
© 1999 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by de Groot, M. J.M.
Right arrow Articles by Hermens, W. Th.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Groot, M. J.M.
Right arrow Articles by Hermens, W. Th.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1999, European Society of Cardiology

Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates

Monique J.M. de Groota, K.Will H. Wodzigb, Maarten L. Simoonsc, Jan F.C. Glatza and Wim Th. Hermensa,*

aCardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
bDepartment of Clinical Chemistry, Academic Hospital, Maastricht, The Netherlands
cThoraxcenter, Erasmus University Rotterdam, Rotterdam, The Netherlands

* Corresponding author. Tel.: +31-43-388-1650; fax: +31-43-367-0916 w.hermens{at}carim.unimaas.nl

Objective: In patients with acute myocardial infarction (AMI), estimation of infarct size from the early markers, fatty acid-binding protein (FABP) and myoglobin (MYO), usually assumes average (fixed) rate constants (FCR) for protein clearance from plasma. However, individual variation in FCR is large. Renal dysfunction causes slower clearance of FABP and MYO from plasma and, hence, overestimation of infarct size in 20–25% of patients. We investigated whether or not more accurate values of infarct size could be obtained with individually estimated clearance rates. Methods: Concentrations of FABP and MYO and, for comparison, activities of the established cardiac markers, creatine kinase (CK) and {alpha}-hydroxybutyrate dehydrogenase (HBDH), were assayed in serial plasma samples from 138 patients with AMI. Individual FCR values of FABP and MYO were estimated from plasma creatinine concentrations, sex and age. Results: Individual FCR values varied from 0.4 to 2.4 h–1. Use of these individual FCR values significantly improved the correlation between infarct size, as estimated from FABP or MYO on the one hand, and from CK and HBDH on the other. Approximately equal estimates of infarct size were obtained for all four marker proteins. Conclusions: Using individually estimated clearance rates, renal insufficiency no longer hampers calculation of infarct size from FABP and MYO, and reliable estimates of total myocardial damage can be obtained within 24 h after first symptoms.

KEYWORDS AMI, Acute myocardial infarction; AST, Aspartate aminotransferase; FABP, Fatty acid-binding protein; MYO, Myoglobin; HBDH, {alpha}-Hydroxybutyrate dehydrogenase; CK, Creatine kinase; CK-MB, heart-specific form of CK; Q(t), Cumulative protein release into plasma from onset of AMI up to time t; GFR, Glomerular filtration rate; FCR, Fractional catabolic rate constant; TER, (Fractional) transcapillary escape rate constant; ERR, (Fractional) extravascular return rate constant


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Chem.Home page
H. M.E. Azzazy, M. M.A.L. Pelsers, and R. H. Christenson
Unbound Free Fatty Acids and Heart-Type Fatty Acid-Binding Protein: Diagnostic Assays and Clinical Applications
Clin. Chem., January 1, 2006; 52(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. M.A.L. Pelsers, T. Hanhoff, D. Van der Voort, B. Arts, M. Peters, R. Ponds, A. Honig, W. Rudzinski, F. Spener, J. R. de Kruijk, et al.
Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility
Clin. Chem., September 1, 2004; 50(9): 1568 - 1575.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. T Dirksen, G. Laarman, A. W.J van 't Hof, G. Guagliumi, W. A.L Tonino, L. Tavazzi, D. J.G.M Duncker, M. L Simoons, and on behalf of the PARI-MI Investigators
The effect of ITF-1697 on reperfusion in patients undergoing primary angioplasty: Safety and efficacy of a novel tetrapeptide, ITF-1697
Eur. Heart J., March 1, 2004; 25(5): 392 - 400.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. H.C. Diris, C. M. Hackeng, J. P. Kooman, Y. M. Pinto, W. T. Hermens, and M. P. van Dieijen-Visser
Impaired Renal Clearance Explains Elevated Troponin T Fragments in Hemodialysis Patients
Circulation, January 6, 2004; 109(1): 23 - 25.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
M. R. Carnethon, L. S. Kinder, J. M. Fair, R. S. Stafford, and S. P. Fortmann
Symptoms of Depression as a Risk Factor for Incident Diabetes: Findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971-1992
Am. J. Epidemiol., September 1, 2003; 158(5): 416 - 423.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M J M de Groot, A M M Muijtjens, M L Simoons, W T Hermens, and J F C Glatz
Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma
Heart, March 1, 2001; 85(3): 278 - 285.
[Abstract] [Full Text]

Home page
 Cardiovasc ResHome page
A. van der Laarse
Rapid estimation of myocardial infarct size
Cardiovasc Res, November 1, 1999; 44(2): 247 - 248.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.