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Cardiovascular Research 1999 44(2):266-273; doi:10.1016/S0008-6363(99)00219-9
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Actin—myosin interaction

Seiryo Sugiura*

Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan

* Tel.: +81-3-3815-5411; fax: +81-3-3814-0021 sugiura-2im{at}h.u-tokyo.ac.jp

Recent advances in the study of muscle physiology was made possible by the application of novel experimental techniques including in vitro motility assay, molecular biology, and X-ray crystallography. A similar approach was successfully applied in studying the properties of cardiac actin—myosin interaction. Implication in clinical cardiology is also reviewed.

KEYWORDS Cardiomyopathy; Contractile apparatus; Contractile function; Heart failure


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