Skip Navigation

Cardiovascular Research 1999 43(3):621-627; doi:10.1016/S0008-6363(99)00081-4
© 1999 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rakhit, R. D
Right arrow Articles by Marber, M. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rakhit, R. D
Right arrow Articles by Marber, M. S
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1999, European Society of Cardiology

Nitric oxide, nitrates and ischaemic preconditioning

Roby D Rakhit, Richard J Edwards and Michael S Marber*

Department of Cardiology, GKT School of Medicine, KU The Rayne Institute, St.Thomas‘s Hospital, Lambeth Palace Road, London SE1 7EH, UK

* Corresponding author. Tel.: +44-171-922-8191; fax: +44-171-960-5659 m.marber@umds.ac.uk

Received 30 October 1998; accepted 16 December 1998

The first 150 words of the full text of this article appear below.


    1 Introduction
 
In 1986 Furchgott first suggested that endothelial-derived relaxing factor might be nitric oxide (NO) [1]. Since then the remarkable role of nitric oxide (NO) as a modulator of biological phenomena has led to the question of its involvement within the spectrum of cardiovascular disease. The resulting research has implicated NO in atherosclerosis, hypertension, cardiomyopathy, pre-eclampsia, endotoxaemia [2] and cardiac allograft rejection [3] providing important additional insights into the pathogenesis of vascular and heart muscle disease. Although initially characterised in the vasculature NO is present in heart muscle [4] whilst the relative expression of the three isoforms (ncNOS, iNOS, ecNOS) responsible for its synthesis may have important implications in disease pathology. Apart from a cytotoxic role, NO has a role in cytostasis both regulating normal homeostasis and protecting against cell injury [5]. This, has led to the hypothesis that NO is cardioprotective in ischaemic heart disease. In testing this . . . [Full Text of this Article]


    2 Background
 

    3 Early preconditioning
 

    4 Late preconditioning
 

    5 Possible mechanisms of action
 
5.1 Free radical generation
5.2 Lipopolysaccharide
5.3 Adenosine
5.4 Protein kinase C
5.5 Heat shock protein upregulation
5.6 The bradykinin–NO–cGMP hypothesis
5.7 The K ATP channel
5.8 Modulation of mitochondrial function

    6 Clinical perspective: the nitrate controversy
 

    7 Future strategies
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
G. J. Gross and J. N. Peart
KATP channels and myocardial preconditioning: an update
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H921 - H930.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
L. Agullo, D. Garcia-Dorado, N. Escalona, J. Inserte, M. Ruiz-Meana, J. A. Barrabes, M. Mirabet, P. Pina, and J. Soler-Soler
Hypoxia and acidosis impair cGMP synthesis in microvascular coronary endothelial cells
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H917 - H925.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
E Belcher, J Mitchell, and T Evans
Myocardial dysfunction in sepsis: no role for NO?
Heart, June 1, 2002; 87(6): 507 - 509.
[Full Text] [PDF]


Home page
Cardiovasc ResHome page
R. Schulz, M. V Cohen, M. Behrends, J. M Downey, and G. Heusch
Signal transduction of ischemic preconditioning
Cardiovasc Res, November 1, 2001; 52(2): 181 - 198.
[Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
K. Nandagopal, T. M. Dawson, and V. L. Dawson
Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
J. Pharmacol. Exp. Ther., April 12, 2001; 297(2): 474 - 478.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. Lochner, E. Marais, S. Genade, and J. A. Moolman
Nitric oxide: a trigger for classic preconditioning?
Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2752 - H2765.
[Abstract] [Full Text] [PDF]