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Cardiovascular Research 1999 43(1):20-22; doi:10.1016/S0008-6363(99)00127-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Implications of inhomogeneous distribution of IKS and IKr channels in ventricle with respect to effects of class III agents and beta-agonists

Antoni C.G. van Ginnekena,* and Marieke W. Veldkampb

aDepartment of Physiology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, The Netherlands
bDepartment of Experimental Cardiology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, The Netherlands

* Corresponding author. Tel.: +31-20-566-4644; fax: +31-20-691-9319 a.c.vanginneken@amc.uva.nl

Received 1 April 1999; accepted 7 April 1999

The first 10% of the full text of this article appears below.

See article by Cheng et al. ([1], pages 135–147) in this issue.

In this issue of Cardiovascular Research Cheng et al. [1] demonstrate that the electrical properties of single cells isolated from apex and base are different. They show that action potentials elicited at 1 Hz are 40 ms shorter in ventricular myocytes isolated from the base than in myocytes isolated from the apex. This is in line with earlier measurements of the same group. In epicardial electrograms of Langendorff-perfused rabbits hearts they found different QT intervals between ventricular apex and base [2]. Cheng et al. [1] found that tail currents in basal myocytes were larger than in apical myocytes. This indicates that delayed rectifier current IK is larger in basal cells and it explains the shorter basal action potential.


   1 Regional differences
 
Ventricular action . . . [Full Text of this Article]


   2 Class III antiarrhythmic agents
 

   3 Effects of beta-agonists
 

   4 Effect of heart rate
 

   5 Methodological considerations
 

   6 Concluding remarks
 

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