© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
Effects of ventricular pacing-induced tachycardia on aortic mechanics in man
Hippokration Hospital, Department of Cardiology, University of Athens, Athens, Greece
* Corresponding author. Tel.: (+301) 6718694; Fax: (+301) 6457230.
Objective: Effects of pacing-induced tachycardia on left ventricular function have been studied extensively. However, little attention has been focused on aortic elastic properties during heart rate increments. The aim was to determine the effects of right ventricular pacing on the aortic elastic properties. Methods: We studied 14 normal subjects (baseline blood pressure, 129/84±10/6 mmHg; aortic diameter, 23.5/21.3±2.4/1.9 mm) at rest, during rapid right ventricular pacing (at five stepwise heart rate increases of 20 bpm every 2 min) and after 5 min recovery. Shifts as well as changes in the slope and the stiffness constant of the pressure diameter (p–d) relation, derived from simultaneous tip-micromanometer aortic pressure recordings and high-fidelity ultrasonic intravascular aortic diameter recordings, were used as indices of aortic stiffness. Wave reflection was also studied. Results: Aortic pulse pressure and strain significantly decreased after pacing-induced tachycardia (p<0.0001 and <0.05, respectively). During pacing, the slope of the linear p–d relation as well as the stiffness constant were decreased, followed by increases at recovery (p<0.0001). The augmentation index and the aortoventricular coupling ratio were significantly decreased (p<0.0001). Conclusions: Pacing-induced increases in pulse frequency may result in improved aortic distensibility and aortoventricular coupling.
KEYWORDS Pacing; Aorta; Distensibility; Pressure–diameter relationship
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. E. Sharman, J. E. Davies, C. Jenkins, and T. H. Marwick Augmentation Index, Left Ventricular Contractility, and Wave Reflection Hypertension, November 1, 2009; 54(5): 1099 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Edwards, C. R. Mastin, and R. W. Kenefick Wave reflection and central aortic pressure are increased in response to static and dynamic muscle contraction at comparable workloads J Appl Physiol, February 1, 2008; 104(2): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ayer, V. Antic, A. G. Dulloo, B. N. Van Vliet, and J.-P. Montani Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1265 - H1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Giannattasio, A. Vincenti, M. Failla, A. Capra, A. Ciro, S. De Ceglia, G. Gentile, R. Brambilla, and G. Mancia Effects of Heart Rate Changes on Arterial Distensibility in Humans Hypertension, September 1, 2003; 42(3): 253 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zambanini, S. A. McG Thom, A. D. Hughes, K. H. Parker, P. Lantelme, C. Mestre, A. Gressard, H. Milon, and M. Lievre Central Aortic Pressure Influences Pulse Wave Velocity * Response: Pulse Wave Velocity, Heart Rate, and Blood Pressure Hypertension, December 1, 2002; 40 (6): e10 - e11. [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Henriksen, S. Fuglsang, F. Bendtsen, E. Christensen, and S. Moller Arterial compliance in patients with cirrhosis: stroke volume-pulse pressure ratio as simplified index Am J Physiol Gastrointest Liver Physiol, April 1, 2001; 280(4): G584 - G594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. B Wilkinson, H. MacCallum, L. Flint, J. R Cockcroft, D. E Newby, and D. J Webb The influence of heart rate on augmentation index and central arterial pressure in humans J. Physiol., May 15, 2000; 525(1): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Stefanadis, J. Dernellis, E. Tsiamis, L. Diamantopoulos, A. Michaelides, and P. Toutouzas Assessment of Aortic Line of Elasticity Using Polynomial Regression Analysis Circulation, April 18, 2000; 101(15): 1819 - 1825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Stefanadis, J Dernellis, E Tsiamis, C Stratos, L Diamantopoulos, A Michaelides, and P Toutouzas Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease Eur. Heart J., March 1, 2000; 21(5): 390 - 396. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Vavuranakis, C. Stefanadis, E. Triandaphyllidi, K. Toutouzas, and P. Toutouzas Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: Evidence of impaired reactivity to nitroglycerin J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1075 - 1081. [Abstract] [Full Text] [PDF]
|
|